Homeobox B13, also known as HOXB13, is a human gene.cite web | title = Entrez Gene: HOXB13 homeobox B13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10481| accessdate = ]

section_title =
summary_text = This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.cite web | title = Entrez Gene: HOXB13 homeobox B13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10481| accessdate = ]

ee also

* Homeobox


Further reading

citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Zeltser L, Desplan C, Heintz N |title=Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. |journal=Development |volume=122 |issue= 8 |pages= 2475–84 |year= 1996 |pmid= 8756292 |doi=
*cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, "et al." |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448–58 |year= 1997 |pmid= 9343407 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Stelnicki EJ, Arbeit J, Cass DL, "et al." |title=Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. |journal=J. Invest. Dermatol. |volume=111 |issue= 1 |pages= 57–63 |year= 1998 |pmid= 9665387 |doi= 10.1046/j.1523-1747.1998.00238.x
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kömüves LG, Ma XK, Stelnicki E, "et al." |title=HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. |journal=Dev. Dyn. |volume=227 |issue= 2 |pages= 192–202 |year= 2004 |pmid= 12761847 |doi= 10.1002/dvdy.10290
*cite journal | author=Jung C, Kim RS, Lee SJ, "et al." |title=HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. |journal=Cancer Res. |volume=64 |issue= 9 |pages= 3046–51 |year= 2004 |pmid= 15126340 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jung C, Kim RS, Zhang HJ, "et al." |title=HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. |journal=Cancer Res. |volume=64 |issue= 24 |pages= 9185–92 |year= 2005 |pmid= 15604291 |doi= 10.1158/0008-5472.CAN-04-1330
*cite journal | author=Zhao Y, Yamashita T, Ishikawa M |title=Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer. |journal=Oncol. Rep. |volume=13 |issue= 4 |pages= 721–6 |year= 2005 |pmid= 15756448 |doi=
*cite journal | author=Jung C, Kim RS, Zhang H, "et al." |title=HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. |journal=Br. J. Cancer |volume=92 |issue= 12 |pages= 2233–9 |year= 2005 |pmid= 15928669 |doi= 10.1038/sj.bjc.6602631
*cite journal | author=Symmans WF |title=Genomic testing for sensitivity of breast cancer to hormonal therapy. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 1954–5 |year= 2006 |pmid= 16609001 |doi= 10.1158/1078-0432.CCR-06-0289
*cite journal | author=Goetz MP, Suman VJ, Ingle JN, "et al." |title=A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2080–7 |year= 2006 |pmid= 16609019 |doi= 10.1158/1078-0432.CCR-05-1263
*cite journal | author=Cazal C, Sobral AP, de Almeida FC, "et al." |title=The homeobox HOXB13 is expressed in human minor salivary gland. |journal=Oral diseases |volume=12 |issue= 4 |pages= 424–7 |year= 2006 |pmid= 16792730 |doi= 10.1111/j.1601-0825.2005.01218.x
*cite journal | author=Ma XJ, Hilsenbeck SG, Wang W, "et al." |title=The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. |journal=J. Clin. Oncol. |volume=24 |issue= 28 |pages= 4611–9 |year= 2006 |pmid= 17008703 |doi= 10.1200/JCO.2006.06.6944
*cite journal | author=Muthusamy V, Duraisamy S, Bradbury CM, "et al." |title=Epigenetic silencing of novel tumor suppressors in malignant melanoma. |journal=Cancer Res. |volume=66 |issue= 23 |pages= 11187–93 |year= 2007 |pmid= 17145863 |doi= 10.1158/0008-5472.CAN-06-1274
*cite journal | author=Miao J, Wang Z, Provencher H, "et al." |title=HOXB13 promotes ovarian cancer progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 43 |pages= 17093–8 |year= 2007 |pmid= 17942676 |doi= 10.1073/pnas.0707938104

External links


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