TBPL1


TBPL1

TBP-like 1, also known as TBPL1, is a human gene.cite web | title = Entrez Gene: TBPL1 TBP-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9519| accessdate = ]

PBB_Summary
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summary_text = Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.cite web | title = Entrez Gene: TBPL1 TBP-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9519| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ohbayashi T, Makino Y, Tamura TA |title=Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor. |journal=Nucleic Acids Res. |volume=27 |issue= 3 |pages= 750–5 |year= 1999 |pmid= 9889269 |doi=
*cite journal | author=Ohbayashi T, Kishimoto T, Makino Y, "et al." |title=Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 1 |pages= 137–42 |year= 1999 |pmid= 10082669 |doi=
*cite journal | author=Rabenstein MD, Zhou S, Lis JT, Tjian R |title=TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4791–6 |year= 1999 |pmid= 10220372 |doi=
*cite journal | author=Teichmann M, Wang Z, Martinez E, "et al." |title=Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13720–5 |year= 2000 |pmid= 10570139 |doi=
*cite journal | author=Martianov I, Brancorsini S, Gansmuller A, "et al." |title=Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. |journal=Development |volume=129 |issue= 4 |pages= 945–55 |year= 2002 |pmid= 11861477 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Kieffer-Kwon P, Martianov I, Davidson I |title=Cell-specific nucleolar localization of TBP-related factor 2. |journal=Mol. Biol. Cell |volume=15 |issue= 10 |pages= 4356–68 |year= 2005 |pmid= 15269281 |doi= 10.1091/mbc.E04-02-0138
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chong JA, Moran MM, Teichmann M, "et al." |title=TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. |journal=Mol. Cell. Biol. |volume=25 |issue= 7 |pages= 2632–43 |year= 2005 |pmid= 15767669 |doi= 10.1128/MCB.25.7.2632-2643.2005
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

External links

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