HOXA13


HOXA13

Homeobox A13, also known as HOXA13, is a human gene.cite web | title = Entrez Gene: HOXA13 homeobox A13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3209| accessdate = ]

PBB_Summary
section_title =
summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome.cite web | title = Entrez Gene: HOXA13 homeobox A13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3209| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Goodman FR, Scambler PJ |title=Human HOX gene mutations. |journal=Clin. Genet. |volume=59 |issue= 1 |pages= 1–11 |year= 2001 |pmid= 11206481 |doi=
*cite journal | author=Utsch B, Becker K, Brock D, "et al." |title=A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length? |journal=Hum. Genet. |volume=110 |issue= 5 |pages= 488–94 |year= 2002 |pmid= 12073020 |doi= 10.1007/s00439-002-0712-8
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Mortlock DP, Innis JW |title=Mutation of HOXA13 in hand-foot-genital syndrome. |journal=Nat. Genet. |volume=15 |issue= 2 |pages= 179–80 |year= 1997 |pmid= 9020844 |doi= 10.1038/ng0297-179
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Post LC, Innis JW |title=Infertility in adult hypodactyly mice is associated with hypoplasia of distal reproductive structures. |journal=Biol. Reprod. |volume=61 |issue= 6 |pages= 1402–8 |year= 1999 |pmid= 10569982 |doi=
*cite journal | author=de Stanchina E, Gabellini D, Norio P, "et al." |title=Selection of homeotic proteins for binding to a human DNA replication origin. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 667–80 |year= 2000 |pmid= 10835276 |doi= 10.1006/jmbi.2000.3782
*cite journal | author=Goodman FR, Bacchelli C, Brady AF, "et al." |title=Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome. |journal=Am. J. Hum. Genet. |volume=67 |issue= 1 |pages= 197–202 |year= 2000 |pmid= 10839976 |doi=
*cite journal | author=Zhao Y, Potter SS |title=Functional specificity of the Hoxa13 homeobox. |journal=Development |volume=128 |issue= 16 |pages= 3197–207 |year= 2001 |pmid= 11688568 |doi=
*cite journal | author=Fujino T, Suzuki A, Ito Y, "et al." |title=Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). |journal=Blood |volume=99 |issue= 4 |pages= 1428–33 |year= 2002 |pmid= 11830496 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Innis JW, Goodman FR, Bacchelli C, "et al." |title=A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome. |journal=Hum. Mutat. |volume=19 |issue= 5 |pages= 573–4 |year= 2002 |pmid= 11968094 |doi= 10.1002/humu.9036
*cite journal | author=Taketani T, Taki T, Ono R, "et al." |title=The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9. |journal=Genes Chromosomes Cancer |volume=34 |issue= 4 |pages= 437–43 |year= 2002 |pmid= 12112533 |doi= 10.1002/gcc.10077
*cite journal | author=Debeer P, Bacchelli C, Scambler PJ, "et al." |title=Severe digital abnormalities in a patient heterozygous for both a novel missense mutation in HOXD13 and a polyalanine tract expansion in HOXA13. |journal=J. Med. Genet. |volume=39 |issue= 11 |pages= 852–6 |year= 2002 |pmid= 12414828 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

*

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