RFX4


RFX4

Regulatory factor X, 4 (influences HLA class II expression), also known as RFX4, is a human gene.cite web | title = Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5992| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5992| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dotzlaw H, Alkhalaf M, Murphy LC |title=Characterization of estrogen receptor variant mRNAs from human breast cancers. |journal=Mol. Endocrinol. |volume=6 |issue= 5 |pages= 773–85 |year= 1992 |pmid= 1603086 |doi=
*cite journal | author=Reith W, Ucla C, Barras E, "et al." |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230–44 |year= 1994 |pmid= 8289803 |doi=
*cite journal | author=Emery P, Durand B, Mach B, Reith W |title=RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. |journal=Nucleic Acids Res. |volume=24 |issue= 5 |pages= 803–7 |year= 1996 |pmid= 8600444 |doi=
*cite journal | author=Gajiwala KS, Chen H, Cornille F, "et al." |title=Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. |journal=Nature |volume=403 |issue= 6772 |pages= 916–21 |year= 2000 |pmid= 10706293 |doi= 10.1038/35002634
*cite journal | author=Morotomi-Yano K, Yano K, Saito H, "et al." |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836–42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Blackshear PJ, Graves JP, Stumpo DJ, "et al." |title=Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. |journal=Development |volume=130 |issue= 19 |pages= 4539–52 |year= 2003 |pmid= 12925582 |doi= 10.1242/dev.00661
*cite journal | author=Araki R, Takahashi H, Fukumura R, "et al." |title=Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10237–42 |year= 2004 |pmid= 14701801 |doi= 10.1074/jbc.M312761200
*cite journal | author=Glaser B, Kirov G, Bray NJ, "et al." |title=Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. |journal=Mol. Psychiatry |volume=10 |issue= 10 |pages= 920–7 |year= 2005 |pmid= 15940297 |doi= 10.1038/sj.mp.4001689
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Matsushita H, Uenaka A, Ono T, "et al." |title=Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients. |journal=Cancer Sci. |volume=96 |issue= 11 |pages= 801–9 |year= 2006 |pmid= 16271074 |doi= 10.1111/j.1349-7006.2005.00112.x

External links

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  • RFX1 — Regulatory factor X, 1 (influences HLA class II expression), also known as RFX1, is a human gene.cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url =… …   Wikipedia

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