MTF1


MTF1

Metal-regulatory transcription factor 1, also known as MTF1, is a human gene.cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Westin G, Schaffner W |title=A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. |journal=EMBO J. |volume=7 |issue= 12 |pages= 3763–70 |year= 1989 |pmid= 3208749 |doi=
*cite journal | author=Brugnera E, Georgiev O, Radtke F, "et al." |title=Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. |journal=Nucleic Acids Res. |volume=22 |issue= 15 |pages= 3167–73 |year= 1994 |pmid= 8065932 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Chen X, Chu M, Giedroc DP |title=MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex. |journal=Biochemistry |volume=38 |issue= 39 |pages= 12915–25 |year= 1999 |pmid= 10504263 |doi=
*cite journal | author=Otsuka F, Okugaito I, Ohsawa M, "et al." |title=Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 2-3 |pages= 330–40 |year= 2000 |pmid= 11004505 |doi=
*cite journal | author=Saydam N, Georgiev O, Nakano MY, "et al." |title=Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25487–95 |year= 2001 |pmid= 11306562 |doi= 10.1074/jbc.M009154200
*cite journal | author=Saydam N, Adams TK, Steiner F, "et al." |title=Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20438–45 |year= 2002 |pmid= 11923282 |doi= 10.1074/jbc.M110631200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Majumder S, Ghoshal K, Summers D, "et al." |title=Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26216–26 |year= 2003 |pmid= 12716893 |doi= 10.1074/jbc.M302887200
*cite journal | author=Saydam N, Steiner F, Georgiev O, Schaffner W |title=Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 31879–83 |year= 2003 |pmid= 12805380 |doi= 10.1074/jbc.M302138200
*cite journal | author=Chen X, Zhang B, Harmon PM, "et al." |title=A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4515–22 |year= 2004 |pmid= 14610091 |doi= 10.1074/jbc.M308924200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Balamurugan K, Egli D, Selvaraj A, "et al." |title=Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. |journal=Biol. Chem. |volume=385 |issue= 7 |pages= 597–603 |year= 2005 |pmid= 15318808 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S |title=Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. |journal=Oncogene |volume=24 |issue= 13 |pages= 2204–17 |year= 2005 |pmid= 15735762 |doi= 10.1038/sj.onc.1208206
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • MTF1 — Mitochondrial Transcription Factor 1 (Medical » Human Genome) ** Metal responsive Transcription Factor 1 (Medical » Human Genome) * Master Text Format 1 (Computing » Software) …   Abbreviations dictionary

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

  • CREB — redirects here. For other uses, see Clean Renewable Energy Bonds. CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. CREB (cAMP response element binding) is a cellular transcription factor. It… …   Wikipedia

  • MyoD — Myogenic differentiation 1 PDB rendering based on 1mdy …   Wikipedia

  • Oct-4 — POU class 5 homeobox 1 Identifiers Symbols POU5F1; MGC22487; OCT3; OCT4; OTF 3; OTF3; OTF4; Oct 3; Oct 4 External IDs …   Wikipedia

  • Estrogen receptor — 1 (ER alpha) A dimer of the ligand binding region of ERα (PDB rendering based on 3erd). Identifi …   Wikipedia

  • Progesterone receptor — PDB rendering based on 1a28 …   Wikipedia

  • Androgen receptor — Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks).[1] …   Wikipedia

  • NF-κB — Mechanism of NF κB action. In this figure, the NF κB heterodimer between Rel and p50 proteins is used as an example. While in an inactivated state, NF κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the… …   Wikipedia

  • Homeobox protein NANOG — See NANOG (computing) for the network operators group. Nanog homeobox Identifiers Symbols NANOG; External IDs …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.