Metal-regulatory transcription factor 1, also known as MTF1, is a human gene.cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url =| accessdate = ]

section_title =
summary_text = This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Westin G, Schaffner W |title=A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. |journal=EMBO J. |volume=7 |issue= 12 |pages= 3763–70 |year= 1989 |pmid= 3208749 |doi=
*cite journal | author=Brugnera E, Georgiev O, Radtke F, "et al." |title=Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. |journal=Nucleic Acids Res. |volume=22 |issue= 15 |pages= 3167–73 |year= 1994 |pmid= 8065932 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Chen X, Chu M, Giedroc DP |title=MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex. |journal=Biochemistry |volume=38 |issue= 39 |pages= 12915–25 |year= 1999 |pmid= 10504263 |doi=
*cite journal | author=Otsuka F, Okugaito I, Ohsawa M, "et al." |title=Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 2-3 |pages= 330–40 |year= 2000 |pmid= 11004505 |doi=
*cite journal | author=Saydam N, Georgiev O, Nakano MY, "et al." |title=Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25487–95 |year= 2001 |pmid= 11306562 |doi= 10.1074/jbc.M009154200
*cite journal | author=Saydam N, Adams TK, Steiner F, "et al." |title=Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20438–45 |year= 2002 |pmid= 11923282 |doi= 10.1074/jbc.M110631200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Majumder S, Ghoshal K, Summers D, "et al." |title=Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26216–26 |year= 2003 |pmid= 12716893 |doi= 10.1074/jbc.M302887200
*cite journal | author=Saydam N, Steiner F, Georgiev O, Schaffner W |title=Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 31879–83 |year= 2003 |pmid= 12805380 |doi= 10.1074/jbc.M302138200
*cite journal | author=Chen X, Zhang B, Harmon PM, "et al." |title=A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4515–22 |year= 2004 |pmid= 14610091 |doi= 10.1074/jbc.M308924200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Balamurugan K, Egli D, Selvaraj A, "et al." |title=Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. |journal=Biol. Chem. |volume=385 |issue= 7 |pages= 597–603 |year= 2005 |pmid= 15318808 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S |title=Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. |journal=Oncogene |volume=24 |issue= 13 |pages= 2204–17 |year= 2005 |pmid= 15735762 |doi= 10.1038/sj.onc.1208206
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

External links


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