MAX interactor 1, also known as MXI1, is a human gene.cite web | title = Entrez Gene: MXI1 MAX interactor 1| url =| accessdate = ]

section_title =
summary_text = Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.cite web | title = Entrez Gene: MXI1 MAX interactor 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Eagle LR, Yin X, Brothman AR, "et al." |title=Mutation of the MXI1 gene in prostate cancer. |journal=Nat. Genet. |volume=9 |issue= 3 |pages= 249–55 |year= 1995 |pmid= 7773287 |doi= 10.1038/ng0395-249
*cite journal | author=Albarosa R, DiDonato S, Finocchiaro G |title=Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. |journal=Hum. Genet. |volume=95 |issue= 6 |pages= 709–11 |year= 1995 |pmid= 7789959 |doi=
*cite journal | author=Schreiber-Agus N, Chin L, Chen K, "et al." |title=An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. |journal=Cell |volume=80 |issue= 5 |pages= 777–86 |year= 1995 |pmid= 7889571 |doi=
*cite journal | author=Zervos AS, Gyuris J, Brent R |title=Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. |journal=Cell |volume=79 |issue= 2 |pages= following 388 |year= 1994 |pmid= 7954804 |doi=
*cite journal | author=Wechsler DS, Hawkins AL, Li X, "et al." |title=Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. |journal=Genomics |volume=21 |issue= 3 |pages= 669–72 |year= 1994 |pmid= 7959753 |doi= 10.1006/geno.1994.1336
*cite journal | author=Edelhoff S, Ayer DE, Zervos AS, "et al." |title=Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. |journal=Oncogene |volume=9 |issue= 2 |pages= 665–8 |year= 1994 |pmid= 8290278 |doi=
*cite journal | author=Zervos AS, Gyuris J, Brent R |title=Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. |journal=Cell |volume=72 |issue= 2 |pages= 223–32 |year= 1993 |pmid= 8425219 |doi=
*cite journal | author=Wechsler DS, Shelly CA, Dang CV |title=Genomic organization of human MXI1, a putative tumor suppressor gene. |journal=Genomics |volume=32 |issue= 3 |pages= 466–70 |year= 1997 |pmid= 8838813 |doi= 10.1006/geno.1996.0144
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Shimizu E, Shirasawa H, Kodama K, "et al." |title=Expression, regulation and polymorphism of the mxi1 genes. |journal=Gene |volume=176 |issue= 1-2 |pages= 45–8 |year= 1997 |pmid= 8918230 |doi=
*cite journal | author=Gupta K, Anand G, Yin X, "et al." |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. |journal=Oncogene |volume=16 |issue= 9 |pages= 1149–59 |year= 1998 |pmid= 9528857 |doi= 10.1038/sj.onc.1201634
*cite journal | author=Schreiber-Agus N, Meng Y, Hoang T, "et al." |title=Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. |journal=Nature |volume=393 |issue= 6684 |pages= 483–7 |year= 1998 |pmid= 9624006 |doi= 10.1038/31008
*cite journal | author=Prochownik EV, Eagle Grove L, Deubler D, "et al." |title=Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. |journal=Genes Chromosomes Cancer |volume=22 |issue= 4 |pages= 295–304 |year= 1999 |pmid= 9669667 |doi=
*cite journal | author=Li XJ, Wang DY, Zhu Y, "et al." |title=Mxi1 mutations in human neurofibrosarcomas. |journal=Jpn. J. Cancer Res. |volume=90 |issue= 7 |pages= 740–6 |year= 1999 |pmid= 10470286 |doi=
*cite journal | author=Benson LQ, Coon MR, Krueger LM, "et al." |title=Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28794–802 |year= 1999 |pmid= 10497252 |doi=
*cite journal | author=Taj MM, Tawil RJ, Engstrom LD, "et al." |title=Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells. |journal=Prostate |volume=47 |issue= 3 |pages= 194–204 |year= 2001 |pmid= 11351349 |doi= 10.1002/pros.1063
*cite journal | author=Yin X, Landay MF, Han W, "et al." |title=Dynamic in vivo interactions among Myc network members. |journal=Oncogene |volume=20 |issue= 34 |pages= 4650–64 |year= 2001 |pmid= 11498788 |doi= 10.1038/sj.onc.1204606
*cite journal | author=Manni I, Tunici P, Cirenei N, "et al." |title=Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. |journal=Br. J. Cancer |volume=86 |issue= 3 |pages= 477–84 |year= 2002 |pmid= 11875718 |doi= 10.1038/sj.bjc.6600065
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ariyanayagam-Baksh SM, Baksh FK, Swalsky PA, Finkelstein SD |title=Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma. |journal=Mod. Pathol. |volume=16 |issue= 10 |pages= 992–5 |year= 2004 |pmid= 14559981 |doi= 10.1097/01.MP.0000087421.44975.1C

External links


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