T-box


T-box

Pfam_box
Symbol = T-box
Name = T-box



width =
caption = Crystallographic structure of the TBX3 protein dimer (cyan and green) complexed with DNA (brown) based on the PDB|1h6f coordinates.
Pfam= PF00907
InterPro= IPR001699
SMART=
PROSITE = PS50252
SCOP = 1xbr
TCDB =
PDB = PDB2|1h6f, PDB2|1xbr

T-box refers to a group of transcription factors involved in limb and heart development.cite journal | author = Wilson V, Conlon FL | title = The T-box family | journal = Genome Biol. | volume = 3 | issue = 6 | pages = REVIEWS3008 | year = 2002 | pmid = 12093383 | pmc = 139375 | doi = 10.1186/gb-2002-3-6-reviews3008 | url = | issn = ] In humans and some other animals, defects in the TBX5 gene expression can lead to finger-like thumbs and ventricular septal defects in which there is no separation between the left and right ventricle of the heart.

Genes include:
* TBX1 (Gene|TBX1)
* TBX2 (Gene|TBX2)
* TBX3 (Gene|TBX3)
* TBX4 (Gene|TBX4)
* TBX5 (Gene|TBX5)
* TBX6 (Gene|TBX6)
* TBX10 (Gene|TBX10)
* TBX15 (Gene|TBX15)
* TBX18 (Gene|TBX18)
* TBX19 (Gene|TBX19)
* TBX20 (Gene|TBX20)
* TBX21 (Gene|TBX21)
* TBX22 (Gene|TBX22)

ee also

* Homeobox
* Development genes in plants: G-box I-box W-box Z-box

References

External links

*


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