Sterol regulatory element binding transcription factor 1, also known as SREBF1, is a human gene.

section_title =
summary_text = This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1| url =| accessdate = ]

ee also

* Sterol regulatory element binding protein


Further reading

citations =
*cite journal | author=Osborne TF |title=CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin. |journal=Genes Dev. |volume=15 |issue= 15 |pages= 1873–8 |year= 2001 |pmid= 11485982 |doi= 10.1101/gad.916601
*cite journal | author=Kotzka J, Müller-Wieland D |title=Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance? |journal=Expert Opin. Ther. Targets |volume=8 |issue= 2 |pages= 141–9 |year= 2006 |pmid= 15102555 |doi= 10.1517/14728222.8.2.141
*cite journal | author=Szolkiewicz M, Chmielewski M, Nogalska A, "et al." |title=The potential role of sterol regulatory element binding protein transcription factors in renal injury. |journal=Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation |volume=17 |issue= 1 |pages= 62–5 |year= 2007 |pmid= 17198935 |doi= 10.1053/j.jrn.2006.10.009
*cite journal | author=Ferré P, Foufelle F |title=SREBP-1c transcription factor and lipid homeostasis: clinical perspective. |journal=Horm. Res. |volume=68 |issue= 2 |pages= 72–82 |year= 2007 |pmid= 17344645 |doi= 10.1159/000100426
*cite journal | author=Hua X, Wu J, Goldstein JL, "et al." |title=Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. |journal=Genomics |volume=25 |issue= 3 |pages= 667–73 |year= 1995 |pmid= 7759101 |doi=
*cite journal | author=Hua X, Yokoyama C, Wu J, "et al." |title=SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 24 |pages= 11603–7 |year= 1994 |pmid= 7903453 |doi=
*cite journal | author=Sato R, Yang J, Wang X, "et al." |title=Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17267–73 |year= 1994 |pmid= 8006035 |doi=
*cite journal | author=Wang X, Sato R, Brown MS, "et al." |title=SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. |journal=Cell |volume=77 |issue= 1 |pages= 53–62 |year= 1994 |pmid= 8156598 |doi=
*cite journal | author=Wang X, Briggs MR, Hua X, "et al." |title=Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. |journal=J. Biol. Chem. |volume=268 |issue= 19 |pages= 14497–504 |year= 1993 |pmid= 8314806 |doi=
*cite journal | author=Yokoyama C, Wang X, Briggs MR, "et al." |title=SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. |journal=Cell |volume=75 |issue= 1 |pages= 187–97 |year= 1993 |pmid= 8402897 |doi=
*cite journal | author=Hua X, Sakai J, Brown MS, Goldstein JL |title=Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10379–84 |year= 1996 |pmid= 8626610 |doi=
*cite journal | author=Shimomura I, Shimano H, Horton JD, "et al." |title=Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. |journal=J. Clin. Invest. |volume=99 |issue= 5 |pages= 838–45 |year= 1997 |pmid= 9062340 |doi=
*cite journal | author=Miserez AR, Cao G, Probst LC, Hobbs HH |title=Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). |journal=Genomics |volume=40 |issue= 1 |pages= 31–40 |year= 1997 |pmid= 9070916 |doi= 10.1006/geno.1996.4525
*cite journal | author=Párraga A, Bellsolell L, Ferré-D'Amaré AR, Burley SK |title=Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution. |journal=Structure |volume=6 |issue= 5 |pages= 661–72 |year= 1998 |pmid= 9634703 |doi=
*cite journal | author=Ericsson J, Edwards PA |title=CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17865–70 |year= 1998 |pmid= 9651391 |doi=
*cite journal | author=Bennett MK, Ngo TT, Athanikar JN, "et al." |title=Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13025–32 |year= 1999 |pmid= 10224053 |doi=
*cite journal | author=Moldes M, Boizard M, Liepvre XL, "et al." |title=Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. |journal=Biochem. J. |volume=344 Pt 3 |issue= |pages= 873–80 |year= 2000 |pmid= 10585876 |doi=
*cite journal | author=DeBose-Boyd RA, Brown MS, Li WP, "et al." |title=Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. |journal=Cell |volume=99 |issue= 7 |pages= 703–12 |year= 2000 |pmid= 10619424 |doi=
*cite journal | author=Roth G, Kotzka J, Kremer L, "et al." |title=MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33302–7 |year= 2000 |pmid= 10915800 |doi= 10.1074/jbc.M005425200
*cite journal | author=Shimomura I, Matsuda M, Hammer RE, "et al." |title=Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. |journal=Mol. Cell |volume=6 |issue= 1 |pages= 77–86 |year= 2000 |pmid= 10949029 |doi=

External links


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