Inhibitor of growth family, member 1, also known as ING1, is a human gene.cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url =| accessdate = ]

section_title =
summary_text = This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Campos EI, Chin MY, Kuo WH, Li G |title=Biological functions of the ING family tumor suppressors. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2597–613 |year= 2004 |pmid= 15526165 |doi= 10.1007/s00018-004-4199-4
*cite journal | author=Garkavtsev I, Kazarov A, Gudkov A, Riabowol K |title=Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. |journal=Nat. Genet. |volume=14 |issue= 4 |pages= 415–20 |year= 1997 |pmid= 8944021 |doi= 10.1038/ng1296-415
*cite journal | author=Helbing CC, Veillette C, Riabowol K, "et al." |title=A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. |journal=Cancer Res. |volume=57 |issue= 7 |pages= 1255–8 |year= 1997 |pmid= 9102209 |doi=
*cite journal | author=Garkavtsev I, Riabowol K |title=Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 2014–9 |year= 1997 |pmid= 9121449 |doi=
*cite journal | author=Garkavtsev I, Demetrick D, Riabowol K |title=Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 176–8 |year= 1997 |pmid= 9186514 |doi=
*cite journal | author=Zeremski M, Horrigan SK, Grigorian IA, "et al." |title=Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 3 |pages= 233–6 |year= 1997 |pmid= 9330636 |doi=
*cite journal | author=Garkavtsev I, Grigorian IA, Ossovskaya VS, "et al." |title=The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. |journal=Nature |volume=391 |issue= 6664 |pages= 295–8 |year= 1998 |pmid= 9440695 |doi= 10.1038/34675
*cite journal | author=Shinoura N, Muramatsu Y, Nishimura M, "et al." |title=Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas. |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5521–8 |year= 1999 |pmid= 10554029 |doi=
*cite journal | author=Jäger D, Stockert E, Scanlan MJ, "et al." |title=Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. |journal=Cancer Res. |volume=59 |issue= 24 |pages= 6197–204 |year= 2000 |pmid= 10626813 |doi=
*cite journal | author=Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D |title=Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions. |journal=Genes Chromosomes Cancer |volume=27 |issue= 3 |pages= 319–22 |year= 2000 |pmid= 10679922 |doi=
*cite journal | author=Tokunaga E, Maehara Y, Oki E, "et al." |title=Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers. |journal=Cancer Lett. |volume=152 |issue= 1 |pages= 15–22 |year= 2000 |pmid= 10754201 |doi=
*cite journal | author=Baranova AV, Ivanov DV, Makeeva NV, "et al." |title= [Genomic organization of the suppressor gene for tumor growth ING1] |journal=Mol. Biol. (Mosk.) |volume=34 |issue= 2 |pages= 263–9 |year= 2000 |pmid= 10779953 |doi=
*cite journal | author=Saito A, Furukawa T, Fukushige S, "et al." |title=p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. |journal=J. Hum. Genet. |volume=45 |issue= 3 |pages= 177–81 |year= 2000 |pmid= 10807544 |doi=
*cite journal | author=Gunduz M, Ouchida M, Fukushima K, "et al." |title=Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. |journal=Cancer Res. |volume=60 |issue= 12 |pages= 3143–6 |year= 2000 |pmid= 10866301 |doi=
*cite journal | author=Skowyra D, Zeremski M, Neznanov N, "et al." |title=Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8734–9 |year= 2001 |pmid= 11118440 |doi= 10.1074/jbc.M007664200
*cite journal | author=Nagashima M, Shiseki M, Miura K, "et al." |title=DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9671–6 |year= 2001 |pmid= 11481424 |doi= 10.1073/pnas.161151798
*cite journal | author=Scott M, Bonnefin P, Vieyra D, "et al." |title=UV-induced binding of ING1 to PCNA regulates the induction of apoptosis. |journal=J. Cell. Sci. |volume=114 |issue= Pt 19 |pages= 3455–62 |year= 2001 |pmid= 11682605 |doi=
*cite journal | author=Kuzmichev A, Zhang Y, Erdjument-Bromage H, "et al." |title=Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 835–48 |year= 2002 |pmid= 11784859 |doi=
*cite journal | author=Nouman GS, Angus B, Lunec J, "et al." |title=Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues. |journal=Hybrid. Hybridomics |volume=21 |issue= 1 |pages= 1–10 |year= 2002 |pmid= 11991811 |doi= 10.1089/15368590252917584
*cite journal | author=Bromidge T, Lynas C |title=Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies. |journal=Leuk. Res. |volume=26 |issue= 7 |pages= 631–5 |year= 2002 |pmid= 12008079 |doi=

External links


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