T-cell acute lymphocytic leukemia 1, also known as TAL1, is a human gene.cite web | title = Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6886| accessdate = ]

The protein encoded by TAL1 is a basic-helix-loop-helix transcription factor.


Further reading

citations =
*cite journal | author=Green AR, Begley CG |title=SCL and related hemopoietic helix-loop-helix transcription factors. |journal=Int. J. Cell Cloning |volume=10 |issue= 5 |pages= 269–76 |year= 1993 |pmid= 1453013 |doi=
*cite journal | author=Aplan PD, Lombardi DP, Reaman GH, "et al." |title=Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. |journal=Blood |volume=79 |issue= 5 |pages= 1327–33 |year= 1992 |pmid= 1311214 |doi=
*cite journal | author=Aplan PD, Nakahara K, Orkin SH, Kirsch IR |title=The SCL gene product: a positive regulator of erythroid differentiation. |journal=EMBO J. |volume=11 |issue= 11 |pages= 4073–81 |year= 1992 |pmid= 1396592 |doi=
*cite journal | author=Goldfarb AN, Goueli S, Mickelson D, Greenberg JM |title=T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein. |journal=Blood |volume=80 |issue= 11 |pages= 2858–66 |year= 1992 |pmid= 1450410 |doi=
*cite journal | author=Bernard O, Lecointe N, Jonveaux P, "et al." |title=Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. |journal=Oncogene |volume=6 |issue= 8 |pages= 1477–88 |year= 1991 |pmid= 1886719 |doi=
*cite journal | author=Bernard O, Guglielmi P, Jonveaux P, "et al." |title=Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias. |journal=Genes Chromosomes Cancer |volume=1 |issue= 3 |pages= 194–208 |year= 1991 |pmid= 1964581 |doi=
*cite journal | author=Chen Q, Yang CY, Tsan JT, "et al." |title=Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. |journal=J. Exp. Med. |volume=172 |issue= 5 |pages= 1403–8 |year= 1990 |pmid= 2230650 |doi=
*cite journal | author=Aplan PD, Begley CG, Bertness V, "et al." |title=The SCL gene is formed from a transcriptionally complex locus. |journal=Mol. Cell. Biol. |volume=10 |issue= 12 |pages= 6426–35 |year= 1991 |pmid= 2247063 |doi=
*cite journal | author=Chen Q, Cheng JT, Tasi LH, "et al." |title=The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. |journal=EMBO J. |volume=9 |issue= 2 |pages= 415–24 |year= 1990 |pmid= 2303035 |doi=
*cite journal | author=Begley CG, Aplan PD, Denning SM, "et al." |title=The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 10128–32 |year= 1990 |pmid= 2602361 |doi=
*cite journal | author=Finger LR, Kagan J, Christopher G, "et al." |title=Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 13 |pages= 5039–43 |year= 1989 |pmid= 2740341 |doi=
*cite journal | author=Osada H, Grutz G, Axelson H, "et al." |title=Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9585–9 |year= 1995 |pmid= 7568177 |doi=
*cite journal | author=Pulford K, Lecointe N, Leroy-Viard K, "et al." |title=Expression of TAL-1 proteins in human tissues. |journal=Blood |volume=85 |issue= 3 |pages= 675–84 |year= 1995 |pmid= 7833471 |doi=
*cite journal | author=Wadman I, Li J, Bash RO, "et al." |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831–9 |year= 1994 |pmid= 7957052 |doi=
*cite journal | author=Valge-Archer VE, Osada H, Warren AJ, "et al." |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617–21 |year= 1994 |pmid= 8078932 |doi=
*cite journal | author=Cross MA, Heyworth CM, Murrell AM, "et al." |title=Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. |journal=Oncogene |volume=9 |issue= 10 |pages= 3013–6 |year= 1994 |pmid= 8084606 |doi=
*cite journal | author=Hsu HL, Wadman I, Baer R |title=Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3181–5 |year= 1994 |pmid= 8159721 |doi=
*cite journal | author=Hwang LY, Siegelman M, Davis L, "et al." |title=Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. |journal=Oncogene |volume=8 |issue= 11 |pages= 3043–6 |year= 1993 |pmid= 8414504 |doi=
*cite journal | author=Cheng JT, Cobb MH, Baer R |title=Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. |journal=Mol. Cell. Biol. |volume=13 |issue= 2 |pages= 801–8 |year= 1993 |pmid= 8423803 |doi=

External links


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