NKX6-1


NKX6-1
NK6 homeobox 1
Identifiers
Symbols NKX6-1; NKX6.1; NKX6A
External IDs OMIM602563 MGI1206039 HomoloGene4495 GeneCards: NKX6-1 Gene
Orthologs
Species Human Mouse
Entrez 4825 18096
Ensembl ENSG00000163623 ENSMUSG00000035187
UniProt P78426 Q99MA9
RefSeq (mRNA) NM_006168 NM_144955.2
RefSeq (protein) NP_006159 NP_659204.1
Location (UCSC) Chr 4:
85.41 – 85.42 Mb
Chr 5:
102.09 – 102.09 Mb
PubMed search [1] [2]

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[1][2]

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[2]

References

  1. ^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408. 
  2. ^ a b "Entrez Gene: NK6 homeobox 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4825. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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