Hairy/enhancer-of-split related with YRPW motif 2, also known as HEY2, is a human gene.cite web | title = Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23493| accessdate = ]

section_title =
summary_text = This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.cite web | title = Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23493| accessdate = ]


Further reading

citations =
*cite journal | author=Iso T, Kedes L, Hamamori Y |title=HES and HERP families: multiple effectors of the Notch signaling pathway. |journal=J. Cell. Physiol. |volume=194 |issue= 3 |pages= 237–55 |year= 2003 |pmid= 12548545 |doi= 10.1002/jcp.10208
*cite journal | author=Kokubo H, Miyagawa-Tomita S, Johnson RL |title=Hesr, a mediator of the Notch signaling, functions in heart and vessel development. |journal=Trends Cardiovasc. Med. |volume=15 |issue= 5 |pages= 190–4 |year= 2006 |pmid= 16165016 |doi= 10.1016/j.tcm.2005.05.005
*cite journal | author=Leimeister C, Externbrink A, Klamt B, Gessler M |title=Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. |journal=Mech. Dev. |volume=85 |issue= 1-2 |pages= 173–7 |year= 1999 |pmid= 10415358 |doi=
*cite journal | author=Chin MT, Maemura K, Fukumoto S, "et al." |title=Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6381–7 |year= 2000 |pmid= 10692439 |doi=
*cite journal | author=Zhong TP, Rosenberg M, Mohideen MA, "et al." |title=gridlock, an HLH gene required for assembly of the aorta in zebrafish. |journal=Science |volume=287 |issue= 5459 |pages= 1820–4 |year= 2000 |pmid= 10710309 |doi=
*cite journal | author=Steidl C, Leimeister C, Klamt B, "et al." |title=Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. |journal=Genomics |volume=66 |issue= 2 |pages= 195–203 |year= 2000 |pmid= 10860664 |doi= 10.1006/geno.2000.6200
*cite journal | author=Firulli BA, Hadzic DB, McDaid JR, Firulli AB |title=The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33567–73 |year= 2000 |pmid= 10924525 |doi= 10.1074/jbc.M005888200
*cite journal | author=Nakagawa O, McFadden DG, Nakagawa M, "et al." |title=Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13655–60 |year= 2001 |pmid= 11095750 |doi= 10.1073/pnas.250485597
*cite journal | author=Iso T, Sartorelli V, Chung G, "et al." |title=HERP, a new primary target of Notch regulated by ligand binding. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6071–9 |year= 2001 |pmid= 11486044 |doi=
*cite journal | author=Iso T, Sartorelli V, Poizat C, "et al." |title=HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6080–9 |year= 2001 |pmid= 11486045 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takata T, Ishikawa F |title=Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 250–7 |year= 2003 |pmid= 12535671 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Fischer A, Klamt B, Schumacher N, "et al." |title=Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. |journal=Mamm. Genome |volume=15 |issue= 9 |pages= 711–6 |year= 2005 |pmid= 15389319 |doi= 10.1007/s00335-004-2389-x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kokubo H, Miyagawa-Tomita S, Nakazawa M, "et al." |title=Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. |journal=Dev. Biol. |volume=278 |issue= 2 |pages= 301–9 |year= 2005 |pmid= 15680351 |doi= 10.1016/j.ydbio.2004.10.025
*cite journal | author=Doi H, Iso T, Yamazaki M, "et al." |title=HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 11 |pages= 2328–34 |year= 2006 |pmid= 16151017 |doi= 10.1161/01.ATV.0000185829.47163.32
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links


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