Homeobox B3, also known as HOXB3, is a human gene.cite web | title = Entrez Gene: HOXB3 homeobox B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3213| accessdate = ]

section_title =
summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).cite web | title = Entrez Gene: HOXB3 homeobox B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3213| accessdate = ]

ee also

* Homeobox


Further reading

citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Giampaolo A, Acampora D, Zappavigna V, "et al." |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Guazzi S, Lonigro R, Pintonello L, "et al." |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Bingle CD, Gowan S |title=Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter. |journal=Biochem. J. |volume=319 ( Pt 3) |issue= |pages= 669–74 |year= 1996 |pmid= 8920965 |doi=
*cite journal | author=Sauvageau G, Thorsteinsdottir U, Hough MR, "et al." |title=Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. |journal=Immunity |volume=6 |issue= 1 |pages= 13–22 |year= 1997 |pmid= 9052833 |doi=
*cite journal | author=Guazzi S, Pintonello ML, Viganò A, Boncinelli E |title=Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11092–9 |year= 1998 |pmid= 9556594 |doi=
*cite journal | author=Viganò MA, Di Rocco G, Zappavigna V, Mavilio F |title=Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6201–12 |year= 1998 |pmid= 9774637 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Nakamura N, Yoshimi T, Miura T |title=Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3. |journal=Cell Growth Differ. |volume=13 |issue= 4 |pages= 195–203 |year= 2002 |pmid= 11971819 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Pineault N, Abramovich C, Ohta H, Humphries RK |title=Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1907–17 |year= 2004 |pmid= 14966272 |doi=
*cite journal | author=Roche J, Zeng C, Barón A, "et al." |title=Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics. |journal=Leukemia |volume=18 |issue= 6 |pages= 1059–63 |year= 2004 |pmid= 15085154 |doi= 10.1038/sj.leu.2403366
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Speleman F, Cauwelier B, Dastugue N, "et al." |title=A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. |journal=Leukemia |volume=19 |issue= 3 |pages= 358–66 |year= 2005 |pmid= 15674412 |doi= 10.1038/sj.leu.2403657
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

External links


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