Liver receptor homolog-1

Liver receptor homolog-1
Nuclear receptor subfamily 5, group A, member 2

PDB rendering based on 1yok.
Symbols NR5A2; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; LRH1; hB1F-2
External IDs OMIM604453 MGI1346834 HomoloGene20827 IUPHAR: NR5A2 GeneCards: NR5A2 Gene
Species Human Mouse
Entrez 2494 26424
Ensembl ENSG00000116833 ENSMUSG00000026398
UniProt O00482 Q1WLP7
RefSeq (mRNA) NM_003822.3 XM_990082
RefSeq (protein) NP_003813.1 XP_995176
Location (UCSC) Chr 1:
200 – 200.15 Mb
Chr 1:
138.74 – 138.86 Mb
PubMed search [1] [2]

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[1][2] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3]



Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[4][5]


  1. ^ Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Mol. Cell. Biol. 13 (3): 1619–33. PMC 359474. PMID 7680097. 
  2. ^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833. 
  3. ^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581. 
  4. ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243. 
  5. ^ Lee YK, Moore DD (January 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176. 

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