STAT6


STAT6

STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.cite journal | author = Leek JP, Hamlin PJ, Bell SM, Lench NJ | title = Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 79 | issue = 3-4 | pages = 208–9 | year = 1997 | pmid = 9605853 | url = | issn = ] cite journal | author = Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL | title = An interleukin-4-induced transcription factor: IL-4 Stat | journal = Science (journal) | volume = 265 | issue = 5179 | pages = 1701–6 | year = 1994 | month = September | pmid = 8085155 | url = http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8085155 | issn = ]

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [cite web | title = Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6778| accessdate = ]

ee also

* interleukin-4

References

Further reading

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citations =
*cite journal | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063–70 |year= 2000 |pmid= 10856136 |doi=
*cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1–24 |year= 2002 |pmid= 12039028 |doi=
*cite journal | author=Hou J, Schindler U, Henzel WJ, "et al." |title=An interleukin-4-induced transcription factor: IL-4 Stat. |journal=Science |volume=265 |issue= 5179 |pages= 1701–6 |year= 1994 |pmid= 8085155 |doi=
*cite journal | author=Takeda K, Tanaka T, Shi W, "et al." |title=Essential role of Stat6 in IL-4 signalling. |journal=Nature |volume=380 |issue= 6575 |pages= 627–30 |year= 1996 |pmid= 8602263 |doi= 10.1038/380627a0
*cite journal | author=Shimoda K, van Deursen J, Sangster MY, "et al." |title=Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. |journal=Nature |volume=380 |issue= 6575 |pages= 630–3 |year= 1996 |pmid= 8602264 |doi= 10.1038/380630a0
*cite journal | author=Kotanides H, Reich NC |title=Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25555–61 |year= 1996 |pmid= 8810328 |doi=
*cite journal | author=Mikita T, Campbell D, Wu P, "et al." |title=Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5811–20 |year= 1996 |pmid= 8816495 |doi=
*cite journal | author=Shen CH, Stavnezer J |title=Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3395–404 |year= 1998 |pmid= 9584180 |doi=
*cite journal | author=Leek JP, Hamlin PJ, Bell SM, Lench NJ |title=Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 208–9 |year= 1998 |pmid= 9605853 |doi=
*cite journal | author=Mikita T, Kurama M, Schindler U |title=Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta. |journal=J. Immunol. |volume=161 |issue= 4 |pages= 1822–8 |year= 1998 |pmid= 9712049 |doi=
*cite journal | author=Patel BK, Keck CL, O'Leary RS, "et al." |title=Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors. |journal=Genomics |volume=52 |issue= 2 |pages= 192–200 |year= 1998 |pmid= 9782085 |doi= 10.1006/geno.1998.5436
*cite journal | author=Zhu M, John S, Berg M, Leonard WJ |title=Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. |journal=Cell |volume=96 |issue= 1 |pages= 121–30 |year= 1999 |pmid= 9989503 |doi=
*cite journal | author=McDonald C, Reich NC |title=Cooperation of the transcriptional coactivators CBP and p300 with Stat6. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 7 |pages= 711–22 |year= 1999 |pmid= 10454341 |doi= 10.1089/107999099313550
*cite journal | author=Harris MB, Chang CC, Berton MT, "et al." |title=Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7264–75 |year= 2000 |pmid= 10490661 |doi=
*cite journal | author=Gupta S, Jiang M, Pernis AB |title=IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. |journal=J. Immunol. |volume=163 |issue= 7 |pages= 3834–41 |year= 1999 |pmid= 10490982 |doi=
*cite journal | author=Gupta S, Jiang M, Anthony A, Pernis AB |title=Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. |journal=J. Exp. Med. |volume=190 |issue= 12 |pages= 1837–48 |year= 2000 |pmid= 10601358 |doi=
*cite journal | author=Daniel C, Salvekar A, Schindler U |title=A gain-of-function mutation in STAT6. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14255–9 |year= 2000 |pmid= 10747856 |doi=
*cite journal | author=Arinobu Y, Sugimoto R, Akaiwa M, "et al." |title=Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 2 |pages= 317–24 |year= 2000 |pmid= 11032724 |doi= 10.1006/bbrc.2000.3674
*cite journal | author=Masuda A, Matsuguchi T, Yamaki K, "et al." |title=Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26107–13 |year= 2001 |pmid= 11369758 |doi= 10.1074/jbc.M011475200

External links

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