E4F transcription factor 1, also known as E4F1, is a human gene.cite web | title = Entrez Gene: E4F1 E4F transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1877| accessdate = ]

section_title =
summary_text = The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.cite web | title = Entrez Gene: E4F1 E4F transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1877| accessdate = ]


Further reading

citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Burn TC, Connors TD, Van Raay TJ, "et al." |title=Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. |journal=Genome Res. |volume=6 |issue= 6 |pages= 525–37 |year= 1996 |pmid= 8828041 |doi=
*cite journal | author=Fernandes ER, Rooney RJ |title=The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1890–903 |year= 1997 |pmid= 9121437 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Rooney RJ, Daniels RR, Jenkins NA, "et al." |title=Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice. |journal=Mamm. Genome |volume=9 |issue= 4 |pages= 320–3 |year= 1998 |pmid= 9530632 |doi=
*cite journal | author=Saccone S, Sandy P, Meroni G, "et al." |title=Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 1-2 |pages= 99–100 |year= 1998 |pmid= 9763670 |doi=
*cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=
*cite journal | author=Sandy P, Gostissa M, Fogal V, "et al." |title=p53 is involved in the p120E4F-mediated growth arrest. |journal=Oncogene |volume=19 |issue= 2 |pages= 188–99 |year= 2000 |pmid= 10644996 |doi= 10.1038/sj.onc.1203250
*cite journal | author=Fajas L, Paul C, Zugasti O, "et al." |title=pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7738–43 |year= 2000 |pmid= 10869426 |doi= 10.1073/pnas.130198397
*cite journal | author=Rizos H, Diefenbach E, Badhwar P, "et al." |title=Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 4981–9 |year= 2003 |pmid= 12446718 |doi= 10.1074/jbc.M210978200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fenton SL, Dallol A, Agathanggelou A, "et al." |title=Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. |journal=Cancer Res. |volume=64 |issue= 1 |pages= 102–7 |year= 2004 |pmid= 14729613 |doi=
*cite journal | author=Nakamura Y, Igarashi K, Suzuki T, "et al." |title=E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. |journal=Am. J. Pathol. |volume=165 |issue= 6 |pages= 2019–31 |year= 2005 |pmid= 15579445 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Paul C, Lacroix M, Iankova I, "et al." |title=The LIM-only protein FHL2 is a negative regulator of E4F1. |journal=Oncogene |volume=25 |issue= 40 |pages= 5475–84 |year= 2006 |pmid= 16652157 |doi= 10.1038/sj.onc.1209567
*cite journal | author=Le Cam L, Linares LK, Paul C, "et al." |title=E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. |journal=Cell |volume=127 |issue= 4 |pages= 775–88 |year= 2006 |pmid= 17110336 |doi= 10.1016/j.cell.2006.09.031
*cite journal | author=Cvetanovic M, Rooney RJ, Garcia JJ, "et al." |title=The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. |journal=EMBO Rep. |volume=8 |issue= 7 |pages= 671–7 |year= 2007 |pmid= 17557114 |doi= 10.1038/sj.embor.7400983

External links


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