HOXA5


HOXA5

Homeobox A5, also known as HOXA5, is a human gene.cite web | title = Entrez Gene: HOXA5 homeobox A5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3202| accessdate = ]

PBB_Summary
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summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.cite web | title = Entrez Gene: HOXA5 homeobox A5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3202| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Tournier-Lasserve E, Odenwald WF, Garbern J, "et al." |title=Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes. |journal=Mol. Cell. Biol. |volume=9 |issue= 5 |pages= 2273–8 |year= 1989 |pmid= 2568583 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Miano JM, Firulli AB, Olson EN, "et al." |title=Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 900–5 |year= 1996 |pmid= 8570656 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Lu Q, Kamps MP |title=Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1632–40 |year= 1996 |pmid= 8657138 |doi=
*cite journal | author=Stelnicki EJ, Kömüves LG, Kwong AO, "et al." |title=HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. |journal=J. Invest. Dermatol. |volume=110 |issue= 2 |pages= 110–5 |year= 1998 |pmid= 9457903 |doi= 10.1046/j.1523-1747.1998.00092.x
*cite journal | author=Crooks GM, Fuller J, Petersen D, "et al." |title=Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. |journal=Blood |volume=94 |issue= 2 |pages= 519–28 |year= 1999 |pmid= 10397719 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Raman V, Tamori A, Vali M, "et al." |title=HOXA5 regulates expression of the progesterone receptor. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26551–5 |year= 2000 |pmid= 10875927 |doi= 10.1074/jbc.C000324200
*cite journal | author=Raman V, Martensen SA, Reisman D, "et al." |title=Compromised HOXA5 function can limit p53 expression in human breast tumours. |journal=Nature |volume=405 |issue= 6789 |pages= 974–8 |year= 2000 |pmid= 10879542 |doi= 10.1038/35016125
*cite journal | author=Golpon HA, Geraci MW, Moore MD, "et al." |title=HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 955–66 |year= 2001 |pmid= 11238043 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Foucher I, Volovitch M, Frain M, "et al." |title=Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors. |journal=Development |volume=129 |issue= 17 |pages= 4065–74 |year= 2002 |pmid= 12163409 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Foucher I, Montesinos ML, Volovitch M, "et al." |title=Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. |journal=Development |volume=130 |issue= 9 |pages= 1867–76 |year= 2003 |pmid= 12642491 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Chen H, Chung S, Sukumar S |title=HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 924–35 |year= 2004 |pmid= 14701762 |doi=

External links

*

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