Thyroid hormone receptor beta


Thyroid hormone receptor beta
Thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

PDB rendering based on 1bsx.
Identifiers
Symbols THRB; ERBA-BETA; ERBA2; GRTH; MGC126109; MGC126110; NR1A2; PRTH; THR1; THRB1; THRB2
External IDs OMIM190160 MGI98743 HomoloGene36025 IUPHAR: NR1A2 GeneCards: THRB Gene
RNA expression pattern
PBB GE THRB 207044 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7068 21834
Ensembl ENSG00000151090 ENSMUSG00000021779
UniProt P10828 Q0VDR8
RefSeq (mRNA) NM_000461.4 NM_009380
RefSeq (protein) NP_000452.2 NP_033406
Location (UCSC) Chr 3:
24.16 – 24.54 Mb
Chr 14:
18.49 – 18.87 Mb
PubMed search [1] [2]

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.[1][2]

Contents

Function

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been observed so far.[1]

Interactions

Thyroid hormone receptor beta has been shown to interact with:

References

  1. ^ a b "Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7067. 
  2. ^ Sakurai A, Nakai A, DeGroot LJ (June 1990). "Structural analysis of human thyroid hormone receptor beta gene". Mol. Cell. Endocrinol. 71 (2): 83–91. doi:10.1016/0303-7207(90)90245-4. PMID 1973914. 
  3. ^ a b Monden T, Wondisford FE, Hollenberg AN (November 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J. Biol. Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056. 
  4. ^ Lin HM, Zhao L, Cheng SY (August 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. 277 (32): 28733–41. doi:10.1074/jbc.M203380200. PMID 12048199. 
  5. ^ a b Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology 139 (10): 4197–204. doi:10.1210/en.139.10.4197. PMID 9751500. 
  6. ^ a b Jeyakumar M, Tanen MR, Bagchi MK (June 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Mol. Endocrinol. 11 (6): 755–67. doi:10.1210/me.11.6.755. PMID 9171239. 
  7. ^ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331. 
  8. ^ Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404. 
  9. ^ Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18584. 
  10. ^ Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi:10.1210/me.16.1.128. PMID 11773444. 
  11. ^ Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. doi:10.1006/bbrc.1998.9799. PMID 9878542. 
  12. ^ Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM (September 2001). "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance". Mol. Endocrinol. 15 (9): 1529–38. doi:10.1210/me.15.9.1529. PMID 11518802. 
  13. ^ Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Mol. Cell. Biol. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85476. 
  14. ^ Wu Y, Delerive P, Chin WW, Burris TP (March 2002). "Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1". J. Biol. Chem. 277 (11): 8898–905. doi:10.1074/jbc.M110761200. PMID 11751919. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Thyroid hormone receptor — protein Name=thyroid hormone receptor, alpha (erythroblastic leukemia viral (v erb a) oncogene homolog, avian) caption= width= HGNCid=11796 Symbol=THRA AltSymbols=THRA1, THRA2, ERBA1 EntrezGene=7067 OMIM=190120 RefSeq=NM 199334 UniProt=P10827 PDB …   Wikipedia

  • Thyroid hormone resistance — MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D018382 Thyroid hormone resistance describes a rare syndrome where the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not… …   Wikipedia

  • Retinoid X receptor beta — Retinoid X receptor, beta PDB rendering based on 1by4 …   Wikipedia

  • Retinoic acid receptor beta — Retinoic acid receptor, beta PDB rendering based on 1dsz …   Wikipedia

  • Liver X receptor beta — Nuclear receptor subfamily 1, group H, member 2 PDB rendering based on 1p8d …   Wikipedia

  • Estrogen-related receptor beta — PDB rendering based on 1lo1 …   Wikipedia

  • Steroid hormone receptor — Steroid hormone receptors are intracellular receptors (typically cytoplasmic) that perform signal transduction for steroid hormones. Steroid hormone receptors are part of the nuclear receptor family that include a group of homologous structured… …   Wikipedia

  • Estrogen receptor beta — See also: Estrogen receptor Estrogen receptor 2 (ER beta) PDB rendering based on 1hj1 …   Wikipedia

  • RAR-related orphan receptor beta — RAR related orphan receptor B PDB rendering based on 1k4w …   Wikipedia

  • Thyroid-stimulating hormone — protein Name = Thyroid stimulating hormone, alpha (Glycoprotein hormones, alpha polypeptide) caption = width = HGNCid = 1885 Symbol = CGA AltSymbols = HCG, GPHa, GPHA1 EntrezGene = 1081 OMIM = 118850 RefSeq = NM 000735 UniProt = P01215 PDB =… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.