Inhibitor of growth family, member 2, also known as ING2, is a human gene.cite web | title = Entrez Gene: ING2 inhibitor of growth family, member 2| url =| accessdate = ]

section_title =
summary_text = This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.cite web | title = Entrez Gene: ING2 inhibitor of growth family, member 2| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Shimada Y, Saito A, Suzuki M, "et al." |title=Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 232–5 |year= 1999 |pmid= 10072587 |doi=
*cite journal | author=Nagashima M, Shiseki M, Miura K, "et al." |title=DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9671–6 |year= 2001 |pmid= 11481424 |doi= 10.1073/pnas.161151798
*cite journal | author=Kuzmichev A, Zhang Y, Erdjument-Bromage H, "et al." |title=Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 835–48 |year= 2002 |pmid= 11784859 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gozani O, Karuman P, Jones DR, "et al." |title=The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. |journal=Cell |volume=114 |issue= 1 |pages= 99–111 |year= 2003 |pmid= 12859901 |doi=
*cite journal | author=Sironi E, Cerri A, Tomasini D, "et al." |title=Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. |journal=J. Cutan. Pathol. |volume=31 |issue= 4 |pages= 318–22 |year= 2004 |pmid= 15005689 |doi=
*cite journal | author=Chattopadhyay C, Hawke D, Kobayashi R, Maity SN |title=Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. |journal=Nucleic Acids Res. |volume=32 |issue= 12 |pages= 3632–41 |year= 2004 |pmid= 15243141 |doi= 10.1093/nar/gkh692
*cite journal | author=He GH, Helbing CC, Wagner MJ, "et al." |title=Phylogenetic analysis of the ING family of PHD finger proteins. |journal=Mol. Biol. Evol. |volume=22 |issue= 1 |pages= 104–16 |year= 2005 |pmid= 15356280 |doi= 10.1093/molbev/msh256
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chin MY, Ng KC, Li G |title=The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. |journal=Exp. Cell Res. |volume=304 |issue= 2 |pages= 531–43 |year= 2005 |pmid= 15748897 |doi= 10.1016/j.yexcr.2004.11.023
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Pedeux R, Sengupta S, Shen JC, "et al." |title=ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6639–48 |year= 2005 |pmid= 16024799 |doi= 10.1128/MCB.25.15.6639-6648.2005
*cite journal | author=Okano T, Gemma A, Hosoya Y, "et al." |title=Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer. |journal=Oncol. Rep. |volume=15 |issue= 3 |pages= 545–9 |year= 2006 |pmid= 16465410 |doi=
*cite journal | author=Wang J, Chin MY, Li G |title=The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. |journal=Cancer Res. |volume=66 |issue= 4 |pages= 1906–11 |year= 2006 |pmid= 16488987 |doi= 10.1158/0008-5472.CAN-05-3444
*cite journal | author=Lu F, Dai DL, Martinka M, "et al." |title=Nuclear ING2 expression is reduced in human cutaneous melanomas. |journal=Br. J. Cancer |volume=95 |issue= 1 |pages= 80–6 |year= 2006 |pmid= 16755297 |doi= 10.1038/sj.bjc.6603205
*cite journal | author=Wang Y, Wang J, Li G |title=Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. |journal=FEBS Lett. |volume=580 |issue= 16 |pages= 3787–93 |year= 2006 |pmid= 16782091 |doi= 10.1016/j.febslet.2006.05.065
*cite journal | author=Huang W, Zhang H, Davrazou F, "et al." |title=Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. |journal=J. Am. Chem. Soc. |volume=129 |issue= 20 |pages= 6498–506 |year= 2007 |pmid= 17469822 |doi= 10.1021/ja070195b

External links


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