Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.cite journal | author = Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R | title = Triggering the interferon response: the role of IRF-3 transcription factor | journal = J. Interferon Cytokine Res. | volume = 19 | issue = 1 | pages = 1–13 | year = 1999 | pmid = 10048763 | doi = 10.1089/107999099314360 | issn = ]

It is a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.cite journal | author = Yoneyama M, Suhara W, Fujita T | title = Control of IRF-3 activation by phosphorylation | journal = J. Interferon Cytokine Res. | volume = 22 | issue = 1 | pages = 73–6 | year = 2002 | pmid = 11846977 | doi = 10.1089/107999002753452674 | issn = ] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [cite web | title = Entrez Gene: IRF3 interferon regulatory factor 3| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Pitha PM, Au WC, Lowther W, "et al." |title=Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 651–8 |year= 1999 |pmid= 9865487 |doi=
*cite journal | author=Yoneyama M, Suhara W, Fujita T |title=Control of IRF-3 activation by phosphorylation. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 1 |pages= 73–6 |year= 2002 |pmid= 11846977 |doi= 10.1089/107999002753452674
*cite journal | author=Au WC, Moore PA, Lowther W, "et al." |title=Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11657–61 |year= 1996 |pmid= 8524823 |doi=
*cite journal | author=Yoneyama M, Suhara W, Fukuhara Y, "et al." |title=Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. |journal=EMBO J. |volume=17 |issue= 4 |pages= 1087–95 |year= 1998 |pmid= 9463386 |doi= 10.1093/emboj/17.4.1087
*cite journal | author=Weaver BK, Kumar KP, Reich NC |title=Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1359–68 |year= 1998 |pmid= 9488451 |doi=
*cite journal | author=Lin R, Heylbroeck C, Pitha PM, Hiscott J |title=Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2986–96 |year= 1998 |pmid= 9566918 |doi=
*cite journal | author=Ronco LV, Karpova AY, Vidal M, Howley PM |title=Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. |journal=Genes Dev. |volume=12 |issue= 13 |pages= 2061–72 |year= 1998 |pmid= 9649509 |doi=
*cite journal | author=Bellingham J, Gregory-Evans K, Gregory-Evans CY |title=Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. |journal=Ann. Hum. Genet. |volume=62 |issue= Pt 3 |pages= 231–4 |year= 1999 |pmid= 9803267 |doi= 10.1046/j.1469-1809.1998.6230231.x
*cite journal | author=Lowther WJ, Moore PA, Carter KC, Pitha PM |title=Cloning and functional analysis of the human IRF-3 promoter. |journal=DNA Cell Biol. |volume=18 |issue= 9 |pages= 685–92 |year= 1999 |pmid= 10492399 |doi= 10.1089/104454999314962
*cite journal | author=Kim T, Kim TY, Song YH, "et al." |title=Activation of interferon regulatory factor 3 in response to DNA-damaging agents. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30686–9 |year= 1999 |pmid= 10521456 |doi=
*cite journal | author=Kumar KP, McBride KM, Weaver BK, "et al." |title=Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 4159–68 |year= 2000 |pmid= 10805757 |doi=
*cite journal | author=Suhara W, Yoneyama M, Iwamura T, "et al." |title=Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. |journal=J. Biochem. |volume=128 |issue= 2 |pages= 301–7 |year= 2000 |pmid= 10920266 |doi=
*cite journal | author=Servant MJ, ten Oever B, LePage C, "et al." |title=Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 355–63 |year= 2001 |pmid= 11035028 |doi= 10.1074/jbc. M007790200
*cite journal | author=Smith EJ, Marié I, Prakash A, "et al." |title=IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8951–7 |year= 2001 |pmid= 11124948 |doi= 10.1074/jbc. M008717200
*cite journal | author=Au WC, Yeow WS, Pitha PM |title=Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. |journal=Virology |volume=280 |issue= 2 |pages= 273–82 |year= 2001 |pmid= 11162841 |doi= 10.1006/viro.2000.0782
*cite journal | author=Barnes BJ, Moore PA, Pitha PM |title=Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23382–90 |year= 2001 |pmid= 11303025 |doi= 10.1074/jbc. M101216200
*cite journal | author=Mach CM, Hargrove BW, Kunkel GR |title=The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4853–8 |year= 2002 |pmid= 11724783 |doi= 10.1074/jbc. M108308200
*cite journal | author=Morin P, Bragança J, Bandu MT, "et al." |title=Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. |journal=J. Mol. Biol. |volume=316 |issue= 5 |pages= 1009–22 |year= 2002 |pmid= 11884139 |doi= 10.1006/jmbi.2001.5401

External links


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