V-erbA-related gene

V-erbA-related gene
Nuclear receptor subfamily 2, group F, member 6
Symbols NR2F6; EAR-2; EAR2; ERBAL2
External IDs OMIM132880 MGI1352453 HomoloGene7706 IUPHAR: NR2F6 GeneCards: NR2F6 Gene
RNA expression pattern
PBB GE NR2F6 209262 s at tn.png
PBB GE NR2F6 209261 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2063 13864
Ensembl ENSG00000160113 ENSMUSG00000002393
UniProt P10588 Q3UIT0
RefSeq (mRNA) NM_005234.3 NM_010150.2
RefSeq (protein) NP_005225.2 NP_034280.2
Location (UCSC) Chr 19:
17.34 – 17.36 Mb
Chr 8:
73.9 – 73.91 Mb
PubMed search [1] [2]

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.[1] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors.



Comparatively little is known about ear-2, but is has been shown to function as a coregulator of other nuclear receptors.[2][3]

Nr2f6 knockout mice show defects in development of the locus ceruleus.[4]


V-erbA-related gene has been shown to interact with:


  1. ^ Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Res. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=338996. 
  2. ^ a b Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Mol. Cell. Biol. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85476. 
  3. ^ Liu X, Huang X, Sigmund CD (2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circ. Res. 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040. 
  4. ^ Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G (March 2005). "Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception". Genes Dev. 19 (5): 614–25. doi:10.1101/gad.317905. PMC 551581. PMID 15741322. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=551581. 
  5. ^ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2823254. 

Further reading

External links

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