Heart and neural crest derivatives expressed 1, also known as HAND1, is a human gene.cite web | title = Entrez Gene: HAND1 heart and neural crest derivatives expressed 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9421| accessdate = ]

section_title =
summary_text = The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.cite web | title = Entrez Gene: HAND1 heart and neural crest derivatives expressed 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9421| accessdate = ]


Further reading

citations =
*cite journal | author=Srivastava D |title=HAND proteins: molecular mediators of cardiac development and congenital heart disease. |journal=Trends Cardiovasc. Med. |volume=9 |issue= 1-2 |pages= 11–8 |year= 1999 |pmid= 10189962 |doi=
*cite journal | author=Weber MC, de Clarke V, Harwin RM, Shiff CJ |title=An extended field trial of pyrimethamine combined with dapsone in the prophylaxis of malaria. |journal=The Central African journal of medicine |volume=21 |issue= 9 |pages= 187–92 |year= 1976 |pmid= 1182795 |doi=
*cite journal | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236
*cite journal | author=Russell MW, Baker P, Izumo S |title=Cloning, chromosomal mapping, and expression of the human eHAND gene. |journal=Mamm. Genome |volume=8 |issue= 11 |pages= 863–5 |year= 1998 |pmid= 9337404 |doi=
*cite journal | author=Knöfler M, Meinhardt G, Vasicek R, "et al." |title=Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart. |journal=Gene |volume=224 |issue= 1-2 |pages= 77–86 |year= 1999 |pmid= 9931445 |doi=
*cite journal | author=Scott IC, Anson-Cartwright L, Riley P, "et al." |title=The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 530–41 |year= 2000 |pmid= 10611232 |doi=
*cite journal | author=Bounpheng MA, Morrish TA, Dodds SG, Christy BA |title=Negative regulation of selected bHLH proteins by eHAND. |journal=Exp. Cell Res. |volume=257 |issue= 2 |pages= 320–31 |year= 2000 |pmid= 10837146 |doi= 10.1006/excr.2000.4898
*cite journal | author=Firulli BA, Hadzic DB, McDaid JR, Firulli AB |title=The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33567–73 |year= 2000 |pmid= 10924525 |doi= 10.1074/jbc.M005888200
*cite journal | author=Knöfler M, Meinhardt G, Bauer S, "et al." |title=Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 641–51 |year= 2002 |pmid= 11802795 |doi=
*cite journal | author=Dai YS, Cserjesi P |title=The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12604–12 |year= 2002 |pmid= 11812799 |doi= 10.1074/jbc.M200283200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Srivastava D, Gottlieb PD, Olson EN |title=Molecular mechanisms of ventricular hypoplasia. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=67 |issue= |pages= 121–5 |year= 2003 |pmid= 12858532 |doi=
*cite journal | author=Firulli BA, Howard MJ, McDaid JR, "et al." |title=PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1225–37 |year= 2004 |pmid= 14636580 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hill AA, Riley PR |title=Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. |journal=Mol. Cell. Biol. |volume=24 |issue= 22 |pages= 9835–47 |year= 2004 |pmid= 15509787 |doi= 10.1128/MCB.24.22.9835-9847.2004
*cite journal | author=Morin S, Pozzulo G, Robitaille L, "et al." |title=MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. |journal=J. Biol. Chem. |volume=280 |issue= 37 |pages= 32272–8 |year= 2005 |pmid= 16043483 |doi= 10.1074/jbc.M507640200

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