ATF3


ATF3

Activating transcription factor 3, also known as ATF3, is a human gene.

PBB_Summary
section_title =
summary_text = Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.cite web | title = Entrez Gene: ATF3 activating transcription factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=467| accessdate = ]

ee also

* Activating transcription factor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hai TW, Liu F, Coukos WJ, Green MR |title=Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. |journal=Genes Dev. |volume=3 |issue= 12B |pages= 2083–90 |year= 1990 |pmid= 2516827 |doi=
*cite journal | author=Chen BP, Liang G, Whelan J, Hai T |title=ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. |journal=J. Biol. Chem. |volume=269 |issue= 22 |pages= 15819–26 |year= 1994 |pmid= 7515060 |doi=
*cite journal | author=Kaszubska W, Hooft van Huijsduijnen R, Ghersa P, "et al." |title=Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines. |journal=Mol. Cell. Biol. |volume=13 |issue= 11 |pages= 7180–90 |year= 1993 |pmid= 7692236 |doi=
*cite journal | author=Chu HM, Tan Y, Kobierski LA, "et al." |title=Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression. |journal=Mol. Endocrinol. |volume=8 |issue= 1 |pages= 59–68 |year= 1994 |pmid= 8152431 |doi=
*cite journal | author=Liang G, Wolfgang CD, Chen BP, "et al." |title=ATF3 gene. Genomic organization, promoter, and regulation. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1695–701 |year= 1996 |pmid= 8576171 |doi=
*cite journal | author=Chen BP, Wolfgang CD, Hai T |title=Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1157–68 |year= 1996 |pmid= 8622660 |doi=
*cite journal | author=Hagmeyer BM, Duyndam MC, Angel P, "et al." |title=Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3. |journal=Oncogene |volume=12 |issue= 5 |pages= 1025–32 |year= 1996 |pmid= 8649793 |doi=
*cite journal | author=Allan AL, Albanese C, Pestell RG, LaMarre J |title=Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27272–80 |year= 2001 |pmid= 11375399 |doi= 10.1074/jbc.M103196200
*cite journal | author=Zhang C, Kawauchi J, Adachi MT, "et al." |title=Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 3 |pages= 718–24 |year= 2002 |pmid= 11726207 |doi= 10.1006/bbrc.2001.6044
*cite journal | author=Yan C, Wang H, Boyd DD |title=ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 10804–12 |year= 2002 |pmid= 11792711 |doi= 10.1074/jbc.M112069200
*cite journal | author=Shaheduzzaman S, Krishnan V, Petrovic A, "et al." |title=Effects of HIV-1 Nef on cellular gene expression profiles. |journal=J. Biomed. Sci. |volume=9 |issue= 1 |pages= 82–96 |year= 2002 |pmid= 11810028 |doi=
*cite journal | author=Hashimoto Y, Zhang C, Kawauchi J, "et al." |title=An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. |journal=Nucleic Acids Res. |volume=30 |issue= 11 |pages= 2398–406 |year= 2002 |pmid= 12034827 |doi=
*cite journal | author=Kawauchi J, Zhang C, Nobori K, "et al." |title=Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 39025–34 |year= 2002 |pmid= 12161427 |doi= 10.1074/jbc.M202974200
*cite journal | author=Zhang C, Gao C, Kawauchi J, "et al." |title=Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1302–10 |year= 2002 |pmid= 12372430 |doi=
*cite journal | author=Fan F, Jin S, Amundson SA, "et al." |title=ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. |journal=Oncogene |volume=21 |issue= 49 |pages= 7488–96 |year= 2002 |pmid= 12386811 |doi= 10.1038/sj.onc.1205896
*cite journal | author=Nobori K, Ito H, Tamamori-Adachi M, "et al." |title=ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. |journal=J. Mol. Cell. Cardiol. |volume=34 |issue= 10 |pages= 1387–97 |year= 2003 |pmid= 12392999 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kang Y, Chen CR, Massagué J |title=A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 915–26 |year= 2003 |pmid= 12718878 |doi=
*cite journal | author=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097–101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648
*cite journal | author=Kool J, Hamdi M, Cornelissen-Steijger P, "et al." |title=Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2. |journal=Oncogene |volume=22 |issue= 27 |pages= 4235–42 |year= 2003 |pmid= 12833146 |doi= 10.1038/sj.onc.1206611

External links

*

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