Oligodendrocyte lineage transcription factor 2
External IDs OMIM606386 MGI1355331 HomoloGene4241 GeneCards: OLIG2 Gene
RNA expression pattern
PBB GE OLIG2 213824 at tn.png
PBB GE OLIG2 213825 at tn.png
More reference expression data
Species Human Mouse
Entrez 10215 50913
Ensembl ENSG00000205927 ENSMUSG00000039830
UniProt Q13516 Q542S0
RefSeq (mRNA) NM_005806 NM_016967.2
RefSeq (protein) NP_005797 NP_058663.2
Location (UCSC) Chr 21:
34.4 – 34.4 Mb
Chr 16:
91.23 – 91.23 Mb
PubMed search [1] [2]

Oligodendrocyte transcription factor 2 is a protein that in humans is encoded by the OLIG2 gene.[1][2]



Oligodendrocyte transcription factor 2 is a basic helix-loop-helix transcription factor. Its expression is predominantly restricted to the central nervous system. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate and is required for oligodendrocyte and motor neuron development.[2]

Clinical signficance

The OLIG2 gene was originally discovered as a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia.[3] Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.[2]

OLIG2 is a universal marker of diffuse gliomas (oligodendroglioma, astrocytoma, glioblastoma, and mixed glioma).[1][4]. The expression in diffuse gliomas is distinct from other types of brain tumors and therefore is clinically useful as a pathologic marker for distinguishing these cancers


  1. ^ a b Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proc Natl Acad Sci U S A 98 (19): 10851–6. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=58563. 
  2. ^ a b c "Entrez Gene: OLIG2 oligodendrocyte lineage transcription factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10215. 
  3. ^ Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD (March 2000). "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3497–502. doi:10.1073/pnas.97.7.3497. PMC 16268. PMID 10737801. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16268. 
  4. ^ Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K (July 2001). "OLIG2 as a specific marker of oligodendroglial tumour cells". Lancet 358 (9278): 298–300. doi:10.1016/S0140-6736(01)05499-X. PMID 11498220. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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