DNA damage-inducible transcript 3


DNA damage-inducible transcript 3
DNA-damage-inducible transcript 3
Identifiers
Symbols DDIT3; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153; MGC4154
External IDs OMIM126337 MGI109247 HomoloGene3012 GeneCards: DDIT3 Gene
RNA expression pattern
PBB GE DDIT3 209383 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1649 13198
Ensembl ENSG00000175197 ENSMUSG00000025408
UniProt P35638 Q3V405
RefSeq (mRNA) NM_001195053.1 NM_007837.3
RefSeq (protein) NP_001181982.1 NP_031863.3
Location (UCSC) Chr 12:
57.91 – 57.91 Mb
Chr 10:
126.73 – 126.73 Mb
PubMed search [1] [2]

DNA damage-inducible transcript 3 is a protein that in humans is encoded by the DDIT3 gene.[1][2]


Contents

Interactions

DNA damage-inducible transcript 3 has been shown to interact with Casein kinase 2, alpha 1,[3] JunD,[4] RPS3A,[5] ATF3,[6] CEBPB,[7][8] C-jun[4] and C-Fos.[4]

References

  1. ^ Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (Mar 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol 11 (2): 1009–16. PMC 359769. PMID 1990262. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359769. 
  2. ^ "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649. 
  3. ^ Ubeda, Mariano; Habener Joel F (Oct. 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation". J. Biol. Chem. (United States) 278 (42): 40514–20. doi:10.1074/jbc.M306404200. ISSN 0021-9258. PMID 12876286. 
  4. ^ a b c Ubeda, M; Vallejo M, Habener J F (Nov. 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMC 84780. PMID 10523647. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84780. 
  5. ^ Cui, K; Coutts M, Stahl J, Sytkowski A J (Mar. 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. (UNITED STATES) 275 (11): 7591–6. doi:10.1074/jbc.275.11.7591. ISSN 0021-9258. PMID 10713066. 
  6. ^ Chen, B P; Wolfgang C D, Hai T (Mar. 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157–68. ISSN 0270-7306. PMC 231098. PMID 8622660. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231098. 
  7. ^ Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. (Netherlands) 541 (1–3): 33–9. doi:10.1016/S0014-5793(03)00283-7. ISSN 0014-5793. PMID 12706815. 
  8. ^ Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. (UNITED STATES) 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. ISSN 0021-9258. PMID 8662954. 

Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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