E2F transcription factor 4, p107/p130-binding, also known as E2F4, is a human gene.

section_title =
summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.cite web | title = Entrez Gene: E2F4 E2F transcription factor 4, p107/p130-binding| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1874| accessdate = ]

ee also

* E2F


Further reading

citations =
*cite journal | author=Bandyopadhyay D, Timchenko N, Suwa T, "et al." |title=The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells. |journal=Exp. Gerontol. |volume=36 |issue= 8 |pages= 1265–75 |year= 2001 |pmid= 11602203 |doi=
*cite journal | author=Sardet C, Vidal M, Cobrinik D, "et al." |title=E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2403–7 |year= 1995 |pmid= 7892279 |doi=
*cite journal | author=Ginsberg D, Vairo G, Chittenden T, "et al." |title=E2F-4, a new member of the E2F transcription factor family, interacts with p107. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2665–79 |year= 1994 |pmid= 7958924 |doi=
*cite journal | author=Beijersbergen RL, Kerkhoven RM, Zhu L, "et al." |title=E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2680–90 |year= 1994 |pmid= 7958925 |doi=
*cite journal | author=Xiao ZX, Ginsberg D, Ewen M, Livingston DM |title=Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4633–7 |year= 1996 |pmid= 8643455 |doi=
*cite journal | author=Moberg K, Starz MA, Lees JA |title=E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1436–49 |year= 1996 |pmid= 8657117 |doi=
*cite journal | author=Vidal M, Brachmann RK, Fattaey A, "et al." |title=Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10315–20 |year= 1996 |pmid= 8816797 |doi=
*cite journal | author=Williams CD, Linch DC, Sørensen TS, "et al." |title=The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. |journal=Br. J. Haematol. |volume=96 |issue= 4 |pages= 688–96 |year= 1997 |pmid= 9074408 |doi=
*cite journal | author=Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D |title=The subcellular localization of E2F-4 is cell-cycle dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5095–100 |year= 1997 |pmid= 9144196 |doi=
*cite journal | author=Wang H, Shao N, Ding QM, "et al." |title=BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. |journal=Oncogene |volume=15 |issue= 2 |pages= 143–57 |year= 1997 |pmid= 9244350 |doi= 10.1038/sj.onc.1201252
*cite journal | author=Müller H, Moroni MC, Vigo E, "et al." |title=Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 5508–20 |year= 1997 |pmid= 9271426 |doi=
*cite journal | author=Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG |title=Differential activities of E2F family members: unique functions in regulating transcription. |journal=Mol. Carcinog. |volume=22 |issue= 3 |pages= 190–8 |year= 1998 |pmid= 9688145 |doi=
*cite journal | author=Ferreira R, Magnaghi-Jaulin L, Robin P, "et al." |title=The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10493–8 |year= 1998 |pmid= 9724731 |doi=
*cite journal | author=Timchenko NA, Wilde M, Darlington GJ |title=C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2936–45 |year= 1999 |pmid= 10082561 |doi=
*cite journal | author=Zheng N, Fraenkel E, Pabo CO, Pavletich NP |title=Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. |journal=Genes Dev. |volume=13 |issue= 6 |pages= 666–74 |year= 1999 |pmid= 10090723 |doi=
*cite journal | author=Furukawa Y, Iwase S, Kikuchi J, "et al." |title=Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes. |journal=Oncogene |volume=18 |issue= 11 |pages= 2003–14 |year= 1999 |pmid= 10208422 |doi= 10.1038/sj.onc.1202500
*cite journal | author=Lam EW, Glassford J, van der Sman J, "et al." |title=Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors. |journal=Eur. J. Immunol. |volume=29 |issue= 10 |pages= 3380–9 |year= 1999 |pmid= 10540350 |doi=
*cite journal | author=Zhong X, Hemmi H, Koike J, "et al." |title=Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4. |journal=Hum. Mutat. |volume=15 |issue= 3 |pages= 296–7 |year= 2000 |pmid= 10679953 |doi= 10.1002/(SICI)1098-1004(200003)15:3<296::AID-HUMU18>3.0.CO;2-X |doilabel=10.1002/(SICI)1098-1004(200003)15:3296::AID-HUMU183.0.CO;2-X
*cite journal | author=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804–16 |year= 2000 |pmid= 10766737 |doi=
*cite journal | author=Schwemmle S, Pfeifer GP |title=Genomic structure and mutation screening of the E2F4 gene in human tumors. |journal=Int. J. Cancer |volume=86 |issue= 5 |pages= 672–7 |year= 2000 |pmid= 10797289 |doi=

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