MAF (gene)

V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
Identifiers
Symbols	MAF; MGC71685; c-MAF
External IDs	OMIM: 177075 MGI: 96909 HomoloGene: 74552 GeneCards: MAF Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding Cellular component • chromatin • nucleus Biological process • transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4094	17132
Ensembl	ENSG00000178573	ENSMUSG00000055435
UniProt	O75444	Q3V1Z2
RefSeq (mRNA)	NM_001031804.2	NM_001025577.2
RefSeq (protein)	NP_001026974.1	NP_001020748.2
Location (UCSC)	Chr 16: 79.63 – 79.63 Mb	Chr 8: 118.21 – 118.23 Mb
PubMed search	[1]	[2]

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.^[1][2]

Types

One type, MafA, also known as RIPE3b1,^[3] promotes pancreatic development, as well as insulin gene transcription.^[4]

Interactions

MAF has been shown to interact with:

• CREBBP^[5]
• EP300^[5]
• MYB^[6]
• SOX9.^[7]

References

1. ^ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4094. 
2. ^ Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (October 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7711–5. doi:10.1073/pnas.86.20.7711. PMC 298140. PMID 2554284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298140. 
3. ^ Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737–42. doi:10.1073/pnas.102168499. PMC 124472. PMID 12011435. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124472. 
4. ^ Melloul D, Marshak S, Cerasi E (March 2002). "Regulation of insulin gene transcription". Diabetologia 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736. 
5. ^ ^{a b} Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (July 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779. 
6. ^ Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation". Mol. Cell. Biol. 18 (5): 2729–37. PMC 110652. PMID 9566892. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110652. 
7. ^ Huang W, Lu N, Eberspaecher H, De Crombrugghe B (December 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". J. Biol. Chem. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733. 

Further reading

• Kerppola TK, Curran T (1994). "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun". Oncogene 9 (3): 675–84. PMID 8108109. 
• Kurschner C, Morgan JI (1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochem. Biophys. Res. Commun. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273. 
• Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998). "c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation". Mol. Cell. Biol. 18 (5): 2729–37. PMC 110652. PMID 9566892. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110652. 
• Chesi M, Bergsagel PL, Shonukan OO et al. (1998). "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma". Blood 91 (12): 4457–63. PMID 9616139. 
• Christodoulopoulos P, Cameron L, Nakamura Y et al. (2001). "TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression". J. Allergy Clin. Immunol. 107 (4): 586–91. doi:10.1067/mai.2001.114883. PMID 11295643. 
• Jamieson RV, Perveen R, Kerr B et al. (2002). "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma". Hum. Mol. Genet. 11 (1): 33–42. doi:10.1093/hmg/11.1.33. PMID 11772997. 
• Chen Q, Dowhan DH, Liang D et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779. 
• Dhakshinamoorthy S, Jaiswal AK (2002). "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction". Oncogene 21 (34): 5301–12. doi:10.1038/sj.onc.1205642. PMID 12149651. 
• Cousins DJ, Lee TH, Staynov DZ (2002). "Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines". J. Immunol. 169 (5): 2498–506. PMID 12193719. 
• Huang W, Lu N, Eberspaecher H, De Crombrugghe B (2003). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". J. Biol. Chem. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG (2003). "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice". Mol. Vis. 9: 288–94. PMID 12835653. 
• Grimbert P, Valanciute A, Audard V et al. (2003). "Truncation of C-mip (Tc-mip), a New Proximal Signaling Protein, Induces c-maf Th2 Transcription Factor and Cytoskeleton Reorganization". J. Exp. Med. 198 (5): 797–807. doi:10.1084/jem.20030566. PMC 1865475. PMID 12939343. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1865475. 
• Valanciuté A, le Gouvello S, Solhonne B et al. (2004). "NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome". J. Immunol. 172 (1): 688–98. PMID 14688382. 
• Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE (2004). "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance". Leuk. Lymphoma 44 (10): 1761–6. doi:10.1080/1042819031000111035. PMID 14692531. 
• Hurt EM, Wiestner A, Rosenwald A et al. (2004). "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma". Cancer Cell 5 (2): 191–9. doi:10.1016/S1535-6108(04)00019-4. PMID 14998494. 
• Cao S, Liu J, Song L, Ma X (2005). "The Protooncogene c-Maf Is an Essential Transcription Factor for IL-10 Gene Expression in Macrophages". J. Immunol. 174 (6): 3484–92. PMC 2955976. PMID 15749884. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2955976. 
• Morito N, Yoh K, Fujioka Y et al. (2006). "Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human". Cancer Res. 66 (2): 812–9. doi:10.1158/0008-5472.CAN-05-2154. PMID 16424013. 
• Vanita V, Singh D, Robinson PN et al. (2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family". Am. J. Med. Genet. A 140 (6): 558–66. doi:10.1002/ajmg.a.31126. PMID 16470690. 

External links

• MeSH MAF+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.