RUNX1T1


RUNX1T1

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related), also known as RUNX1T1, is a human gene.cite web | title = Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=862| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.cite web | title = Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=862| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ferrara F, Del Vecchio L |title=Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity. |journal=Haematologica |volume=87 |issue= 3 |pages= 306–19 |year= 2002 |pmid= 11869944 |doi=
*cite journal | author=Erickson P, Gao J, Chang KS, "et al." |title=Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. |journal=Blood |volume=80 |issue= 7 |pages= 1825–31 |year= 1992 |pmid= 1391946 |doi=
*cite journal | author=Nisson PE, Watkins PC, Sacchi N |title=Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. |journal=Cancer Genet. Cytogenet. |volume=63 |issue= 2 |pages= 81–8 |year= 1992 |pmid= 1423235 |doi=
*cite journal | author=Era T, Asou N, Kunisada T, "et al." |title=Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. |journal=Genes Chromosomes Cancer |volume=13 |issue= 1 |pages= 25–33 |year= 1995 |pmid= 7541640 |doi=
*cite journal | author=Tighe JE, Calabi F |title=Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2. |journal=Blood |volume=84 |issue= 7 |pages= 2115–21 |year= 1994 |pmid= 7919324 |doi=
*cite journal | author=Erickson PF, Robinson M, Owens G, Drabkin HA |title=The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor. |journal=Cancer Res. |volume=54 |issue= 7 |pages= 1782–6 |year= 1994 |pmid= 8137293 |doi=
*cite journal | author=Miyoshi H, Kozu T, Shimizu K, "et al." |title=The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. |journal=EMBO J. |volume=12 |issue= 7 |pages= 2715–21 |year= 1993 |pmid= 8334990 |doi=
*cite journal | author=Kozu T, Miyoshi H, Shimizu K, "et al." |title=Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. |journal=Blood |volume=82 |issue= 4 |pages= 1270–6 |year= 1993 |pmid= 8353289 |doi=
*cite journal | author=Niwa-Kawakita M, Miyoshi H, Gotoh O, "et al." |title=Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia. |journal=Genomics |volume=29 |issue= 3 |pages= 755–9 |year= 1996 |pmid= 8575770 |doi= 10.1006/geno.1995.9941
*cite journal | author=Erickson PF, Dessev G, Lasher RS, "et al." |title=ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease. |journal=Blood |volume=88 |issue= 5 |pages= 1813–23 |year= 1996 |pmid= 8781439 |doi=
*cite journal | author=Wolford JK, Bogardus C, Prochazka M |title=Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males. |journal=Biochem. Biophys. Res. Commun. |volume=246 |issue= 3 |pages= 624–6 |year= 1998 |pmid= 9618262 |doi= 10.1006/bbrc.1998.8683
*cite journal | author=Sacchi N, Tamanini F, Willemsen R, "et al." |title=Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells. |journal=Oncogene |volume=16 |issue= 20 |pages= 2609–15 |year= 1998 |pmid= 9632137 |doi= 10.1038/sj.onc.1201824
*cite journal | author=Wolford JK, Prochazka M |title=Structure and expression of the human MTG8/ETO gene. |journal=Gene |volume=212 |issue= 1 |pages= 103–9 |year= 1998 |pmid= 9661669 |doi=
*cite journal | author=Calabi F, Cilli V |title=CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. |journal=Genomics |volume=52 |issue= 3 |pages= 332–41 |year= 1998 |pmid= 9790752 |doi= 10.1006/geno.1998.5429
*cite journal | author=Komori A, Sueoka E, Fujiki H, "et al." |title=Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines. |journal=Jpn. J. Cancer Res. |volume=90 |issue= 1 |pages= 60–8 |year= 1999 |pmid= 10076566 |doi=
*cite journal | author=Morohoshi F, Mitani S, Mitsuhashi N, "et al." |title=Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. |journal=Gene |volume=241 |issue= 2 |pages= 287–95 |year= 2000 |pmid= 10675041 |doi=
*cite journal | author=Melnick AM, Westendorf JJ, Polinger A, "et al." |title=The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2075–86 |year= 2000 |pmid= 10688654 |doi=
*cite journal | author=Miyamoto T, Weissman IL, Akashi K |title=AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7521–6 |year= 2000 |pmid= 10861016 |doi=
*cite journal | author=Odaka Y, Mally A, Elliott LT, Meyers S |title=Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8). |journal=Oncogene |volume=19 |issue= 32 |pages= 3584–97 |year= 2000 |pmid= 10951564 |doi= 10.1038/sj.onc.1203689
*cite journal | author=Wood JD, Nucifora FC, Duan K, "et al." |title=Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. |journal=J. Cell Biol. |volume=150 |issue= 5 |pages= 939–48 |year= 2000 |pmid= 10973986 |doi=

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