CEBPA


CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha, also known as CEBPA, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [cite web | title = Entrez Gene: CEBPA CCAAT/enhancer binding protein (C/EBP), alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1050| accessdate = ]

ee also

*Ccaat-enhancer-binding proteins

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sladek FM, Darnell JE |title=Mechanisms of liver-specific gene expression. |journal=Curr. Opin. Genet. Dev. |volume=2 |issue= 2 |pages= 256–9 |year= 1992 |pmid= 1638120 |doi=
*cite journal | author=Marcucci G, Mrózek K, Bloomfield CD |title=Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. |journal=Curr. Opin. Hematol. |volume=12 |issue= 1 |pages= 68–75 |year= 2005 |pmid= 15604894 |doi=
*cite journal | author=Leroy H, Roumier C, Huyghe P, "et al." |title=CEBPA point mutations in hematological malignancies. |journal=Leukemia |volume=19 |issue= 3 |pages= 329–34 |year= 2005 |pmid= 15674366 |doi= 10.1038/sj.leu.2403614

External links

*

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