T-box 21, also known as TBX21, is a human gene.cite web | title = Entrez Gene: TBX21 T-box 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30009| accessdate = ]

section_title =
summary_text = This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.cite web | title = Entrez Gene: TBX21 T-box 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30009| accessdate = ]


Further reading

citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Szabo SJ, Kim ST, Costa GL, "et al." |title=A novel transcription factor, T-bet, directs Th1 lineage commitment. |journal=Cell |volume=100 |issue= 6 |pages= 655–69 |year= 2000 |pmid= 10761931 |doi=
*cite journal | author=Zhang WX, Yang SY |title=Cloning and characterization of a new member of the T-box gene family. |journal=Genomics |volume=70 |issue= 1 |pages= 41–8 |year= 2001 |pmid= 11087660 |doi= 10.1006/geno.2000.6361
*cite journal | author=Faedo A, Ficara F, Ghiani M, "et al." |title=Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. |journal=Mech. Dev. |volume=116 |issue= 1-2 |pages= 157–60 |year= 2003 |pmid= 12128215 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chung HT, Kim LH, Park BL, "et al." |title=Association analysis of novel TBX21 variants with asthma phenotypes. |journal=Hum. Mutat. |volume=22 |issue= 3 |pages= 257 |year= 2003 |pmid= 12938094 |doi= 10.1002/humu.9169
*cite journal | author=Yu HR, Chang JC, Chen RF, "et al." |title=Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 952–8 |year= 2004 |pmid= 12960249 |doi= 10.1189/jlb.0902474
*cite journal | author=Lametschwandtner G, Biedermann T, Schwärzler C, "et al." |title=Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. |journal=J. Allergy Clin. Immunol. |volume=113 |issue= 5 |pages= 987–94 |year= 2004 |pmid= 15131585 |doi= 10.1016/j.jaci.2004.02.004
*cite journal | author=Sasaki Y, Ihara K, Matsuura N, "et al." |title=Identification of a novel type 1 diabetes susceptibility gene, T-bet. |journal=Hum. Genet. |volume=115 |issue= 3 |pages= 177–84 |year= 2004 |pmid= 15241679 |doi= 10.1007/s00439-004-1146-2
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Tantisira KG, Hwang ES, Raby BA, "et al." |title=TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 52 |pages= 18099–104 |year= 2005 |pmid= 15604153 |doi= 10.1073/pnas.0408532102
*cite journal | author=Atayar C, Poppema S, Blokzijl T, "et al." |title=Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas. |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 127–34 |year= 2005 |pmid= 15632006 |doi=
*cite journal | author=Tong Y, Aune T, Boothby M |title=T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 6 |pages= 2034–9 |year= 2005 |pmid= 15684083 |doi= 10.1073/pnas.0409510102
*cite journal | author=Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH |title=T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma. |journal=Hum. Pathol. |volume=36 |issue= 1 |pages= 10–5 |year= 2005 |pmid= 15712176 |doi= 10.1016/j.humpath.2004.10.006
*cite journal | author=Kulkarni A, Ravi DS, Singh K, "et al." |title=HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 2 |pages= 706–12 |year= 2005 |pmid= 15737643 |doi= 10.1016/j.bbrc.2005.02.042
*cite journal | author=Akahoshi M, Obara K, Hirota T, "et al." |title=Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. |journal=Hum. Genet. |volume=117 |issue= 1 |pages= 16–26 |year= 2005 |pmid= 15806396 |doi= 10.1007/s00439-005-1285-0
*cite journal | author=Kawana K, Kawana Y, Schust DJ |title=Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. |journal=Mol. Endocrinol. |volume=19 |issue= 8 |pages= 2047–59 |year= 2005 |pmid= 15860546 |doi= 10.1210/me.2004-0489
*cite journal | author=Harashima A, Matsuo Y, Drexler HG, "et al." |title=Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet. |journal=Leuk. Res. |volume=29 |issue= 7 |pages= 841–8 |year= 2005 |pmid= 15927679 |doi= 10.1016/j.leukres.2004.12.010
*cite journal | author=Raby BA, Hwang ES, Van Steen K, "et al." |title=T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. |journal=Am. J. Respir. Crit. Care Med. |volume=173 |issue= 1 |pages= 64–70 |year= 2006 |pmid= 16179640 |doi= 10.1164/rccm.200503-505OC

External links


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Look at other dictionaries:

  • T-box — Pfam box Symbol = T box Name = T box width = caption = Crystallographic structure of the TBX3 protein dimer (cyan and green) complexed with DNA (brown) based on the PDB|1h6f coordinates. Pfam= PF00907 InterPro= IPR001699 SMART= PROSITE = PS50252… …   Wikipedia

  • T-box — Estructura tridimensional de la proteína dimérica TBX3 (azul y verde) unida al ADN (marrón). Identificadores Símbolo T box …   Wikipedia Español

  • Аспириновая бронхиальная астма — МКБ 10 J45.145.1, J45.845.8 МКБ 9 493.1 …   Википедия

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