High mobility group AT-hook 1, also known as HMGA1, is a human gene.

section_title =
summary_text = This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.cite web | title = Entrez Gene: HMGA1 high mobility group AT-hook 1| url =| accessdate = ]

ee also



Further reading

citations =
*cite journal | author=Reeves R, Beckerbauer L |title=HMGI/Y proteins: flexible regulators of transcription and chromatin structure. |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1-2 |pages= 13–29 |year= 2001 |pmid= 11406267 |doi=
*cite journal | author=Hui H, Perfetti R |title=Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. |journal=Eur. J. Endocrinol. |volume=146 |issue= 2 |pages= 129–41 |year= 2002 |pmid= 11834421 |doi=
*cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26–43 |year= 2005 |pmid= 15875659 |doi=
*cite journal | author=Van Maele B, Busschots K, Vandekerckhove L, "et al." |title=Cellular co-factors of HIV-1 integration. |journal=Trends Biochem. Sci. |volume=31 |issue= 2 |pages= 98–105 |year= 2006 |pmid= 16403635 |doi= 10.1016/j.tibs.2005.12.002
*cite journal | author=Reeves R, Nissen MS |title=The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. |journal=J. Biol. Chem. |volume=265 |issue= 15 |pages= 8573–82 |year= 1990 |pmid= 1692833 |doi=
*cite journal | author=Nissen MS, Langan TA, Reeves R |title=Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19945–52 |year= 1991 |pmid= 1939057 |doi=
*cite journal | author=Eckner R, Birnstiel ML |title=Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif. |journal=Nucleic Acids Res. |volume=17 |issue= 15 |pages= 5947–59 |year= 1989 |pmid= 2505228 |doi=
*cite journal | author=Johnson KR, Lehn DA, Reeves R |title=Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y. |journal=Mol. Cell. Biol. |volume=9 |issue= 5 |pages= 2114–23 |year= 1989 |pmid= 2701943 |doi=
*cite journal | author=Palvimo J, Linnala-Kankkunen A |title=Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase II. |journal=FEBS Lett. |volume=257 |issue= 1 |pages= 101–4 |year= 1989 |pmid= 2806554 |doi=
*cite journal | author=Karlson JR, Mørk E, Holtlund J, "et al." |title=The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs. |journal=Biochem. Biophys. Res. Commun. |volume=158 |issue= 3 |pages= 646–51 |year= 1989 |pmid= 2920035 |doi=
*cite journal | author=Lund T, Dahl KH, Mørk E, "et al." |title=The human chromosomal protein HMG I contains two identical palindrome amino acid sequences. |journal=Biochem. Biophys. Res. Commun. |volume=146 |issue= 2 |pages= 725–30 |year= 1987 |pmid= 3619901 |doi=
*cite journal | author=Leger H, Sock E, Renner K, "et al." |title=Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3738–47 |year= 1995 |pmid= 7791781 |doi=
*cite journal | author=John S, Reeves RB, Lin JX, "et al." |title=Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1786–96 |year= 1995 |pmid= 7862168 |doi=
*cite journal | author=Friedmann M, Holth LT, Zoghbi HY, Reeves R |title=Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. |journal=Nucleic Acids Res. |volume=21 |issue= 18 |pages= 4259–67 |year= 1993 |pmid= 8414980 |doi=
*cite journal | author=Farnet CM, Bushman FD |title=HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro. |journal=Cell |volume=88 |issue= 4 |pages= 483–92 |year= 1997 |pmid= 9038339 |doi=
*cite journal | author=Miller MD, Farnet CM, Bushman FD |title=Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. |journal=J. Virol. |volume=71 |issue= 7 |pages= 5382–90 |year= 1997 |pmid= 9188609 |doi=
*cite journal | author=Huth JR, Bewley CA, Nissen MS, "et al." |title=The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif. |journal=Nat. Struct. Biol. |volume=4 |issue= 8 |pages= 657–65 |year= 1997 |pmid= 9253416 |doi=
*cite journal | author=Currie RA |title=Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y). |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30880–8 |year= 1998 |pmid= 9388234 |doi=
*cite journal | author=Chin MT, Pellacani A, Wang H, "et al." |title=Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 9755–60 |year= 1998 |pmid= 9545312 |doi=
*cite journal | author=Chiappetta G, Tallini G, De Biasio MC, "et al." |title=Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. |journal=Cancer Res. |volume=58 |issue= 18 |pages= 4193–8 |year= 1998 |pmid= 9751634 |doi=

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • HMGA1 — — белок, который связывается в клетке с ДНК и определенными белками. Он вовлечен во многие функциональные процессы в клетке, в том числе в защиту клетки от умирания. В некоторых типах раковых клеток выявлен высокий уровень содержания белка HMGA1 …   Генетика. Энциклопедический словарь

  • High mobility group — or HMG is a group of chromosomal proteins that help with transcription, replication, recombination, and DNA repair.cite journal | author = Rajeswari MR, Jain A | title = High mobility group chromosomal proteins, HMGA1 as potential tumour markers… …   Wikipedia

  • SUMO network — consists of enzymes and substrates involved in the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to substrates). Network membersThe SUMO network members (gene name and aliases) as published in the… …   Wikipedia

  • HMGA — protein Name=high mobility group AT hook 1 caption= width= HGNCid=5010 Symbol=HMGA1 AltSymbols=HMGIY EntrezGene=3159 OMIM=600701 RefSeq=NM 145901 UniProt=P17096 PDB= ECnumber= Chromosome=6 Arm=p Band=21 LocusSupplementaryData=protein Name=high… …   Wikipedia

  • let-7 microRNA precursor — Predicted secondary structure and sequence conservation of let 7 Identifiers Symbol let 7 Rfam …   Wikipedia

  • Transcription factor — In the field of molecular biology, a transcription factor (sometimes called a sequence specific DNA binding factor) is a protein that binds to specific sequences of DNA and thereby controls the transfer (or transcription) of genetic information… …   Wikipedia

  • CEBPB — CCAAT/enhancer binding protein (C/EBP), beta PDB rendering based on 1ci6 …   Wikipedia

  • TLX3 — T cell leukemia homeobox 3, also known as TLX3, is a human gene.cite web | title = Entrez Gene: TLX3 T cell leukemia homeobox 3| url = Cmd=ShowDetailView TermToSearch=30012| accessdate = ] PBB… …   Wikipedia

  • BCL11B — B cell CLL/lymphoma 11B (zinc finger protein), also known as BCL11B, is a human gene.cite web | title = Entrez Gene: BCL11B B cell CLL/lymphoma 11B (zinc finger protein)| url = Cmd=ShowDetailView… …   Wikipedia

  • Santa J. Ono — (born November 23, 1962) is an American Canadian biologist and university administrator. He is considered to be a key opinion leader in ocular inflammation and an international authority on allergic conjunctivitis.BiographyBorn in Vancouver,… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.