Heat shock transcription factor 1, also known as HSF1, is a human gene.

section_title =
summary_text = The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [cite web | title = Entrez Gene: HSF1 heat shock transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3297| accessdate = ]

ee also

* Heat shock factor


Further reading

citations =
*cite journal | author=Voellmy R |title=Sensing stress and responding to stress. |journal=EXS |volume=77 |issue= |pages= 121–37 |year= 1996 |pmid= 8856972 |doi=
*cite journal | author=Abravaya K, Myers MP, Murphy SP, Morimoto RI |title=The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. |journal=Genes Dev. |volume=6 |issue= 7 |pages= 1153–64 |year= 1992 |pmid= 1628823 |doi=
*cite journal | author=Rabindran SK, Giorgi G, Clos J, Wu C |title=Molecular cloning and expression of a human heat shock factor, HSF1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 6906–10 |year= 1991 |pmid= 1871105 |doi=
*cite journal | author=Schuetz TJ, Gallo GJ, Sheldon L, "et al." |title=Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 6911–5 |year= 1991 |pmid= 1871106 |doi=
*cite journal | author=Nunes SL, Calderwood SK |title=Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. |journal=Biochem. Biophys. Res. Commun. |volume=213 |issue= 1 |pages= 1–6 |year= 1995 |pmid= 7639722 |doi= 10.1006/bbrc.1995.2090
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Chu B, Soncin F, Price BD, "et al." |title=Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30847–57 |year= 1997 |pmid= 8940068 |doi=
*cite journal | author=Fukunaga R, Hunter T |title=MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1921–33 |year= 1997 |pmid= 9155018 |doi= 10.1093/emboj/16.8.1921
*cite journal | author=Nair SC, Toran EJ, Rimerman RA, "et al." |title=A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. |journal=Cell Stress Chaperones |volume=1 |issue= 4 |pages= 237–50 |year= 1997 |pmid= 9222609 |doi=
*cite journal | author=Huang J, Nueda A, Yoo S, Dynan WS |title=Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 26009–16 |year= 1997 |pmid= 9325337 |doi=
*cite journal | author=Cotto J, Fox S, Morimoto R |title=HSF1 granules: a novel stress-induced nuclear compartment of human cells. |journal=J. Cell. Sci. |volume=110 ( Pt 23) |issue= |pages= 2925–34 |year= 1998 |pmid= 9359875 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Shi Y, Mosser DD, Morimoto RI |title=Molecular chaperones as HSF1-specific transcriptional repressors. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 654–66 |year= 1998 |pmid= 9499401 |doi=
*cite journal | author=Satyal SH, Chen D, Fox SG, "et al." |title=Negative regulation of the heat shock transcriptional response by HSBP1. |journal=Genes Dev. |volume=12 |issue= 13 |pages= 1962–74 |year= 1998 |pmid= 9649501 |doi=
*cite journal | author=Zhou X, Tron VA, Li G, Trotter MJ |title=Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light. |journal=J. Invest. Dermatol. |volume=111 |issue= 2 |pages= 194–8 |year= 1998 |pmid= 9699716 |doi= 10.1046/j.1523-1747.1998.00266.x
*cite journal | author=Zou J, Guo Y, Guettouche T, "et al." |title=Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. |journal=Cell |volume=94 |issue= 4 |pages= 471–80 |year= 1998 |pmid= 9727490 |doi=
*cite journal | author=Stephanou A, Isenberg DA, Nakajima K, Latchman DS |title=Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1723–8 |year= 1999 |pmid= 9880553 |doi=
*cite journal | author=Dai R, Frejtag W, He B, "et al." |title=c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18210–8 |year= 2000 |pmid= 10747973 |doi= 10.1074/jbc.M000958200
*cite journal | author=Choi Y, Asada S, Uesugi M |title=Divergent hTAFII31-binding motifs hidden in activation domains. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 15912–6 |year= 2000 |pmid= 10821850 |doi=

External links


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