ELK4


ELK4

ELK4, ETS-domain protein (SRF accessory protein 1), also known as ELK4, is a human gene.cite web | title = Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2005| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.cite web | title = Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2005| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371–87 |year= 1998 |pmid= 9570133 |doi=
*cite journal | author=Wasylyk B, Hagman J, Gutierrez-Hartmann A |title=Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. |journal=Trends Biochem. Sci. |volume=23 |issue= 6 |pages= 213–6 |year= 1998 |pmid= 9644975 |doi=
*cite journal | author=Dalton S, Treisman R |title=Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. |journal=Cell |volume=68 |issue= 3 |pages= 597–612 |year= 1992 |pmid= 1339307 |doi=
*cite journal | author=Price MA, Rogers AE, Treisman R |title=Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). |journal=EMBO J. |volume=14 |issue= 11 |pages= 2589–601 |year= 1995 |pmid= 7540136 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Shipley J, Sheer D, Dalton S, "et al." |title=Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. |journal=Genomics |volume=23 |issue= 3 |pages= 710–1 |year= 1995 |pmid= 7851904 |doi= 10.1006/geno.1994.1564
*cite journal | author=Dalton S, Treisman R |title=Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. |journal=Cell |volume=76 |issue= 2 |pages= 411 |year= 1994 |pmid= 8293474 |doi=
*cite journal | author=Giovane A, Sobieszczuk P, Mignon C, "et al." |title=Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes. |journal=Genomics |volume=29 |issue= 3 |pages= 769–72 |year= 1996 |pmid= 8575773 |doi= 10.1006/geno.1995.9938
*cite journal | author=Janknecht R, Hunter T |title=Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4219–24 |year= 1997 |pmid= 9020136 |doi=
*cite journal | author=Janknecht R, Hunter T |title=Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. |journal=EMBO J. |volume=16 |issue= 7 |pages= 1620–7 |year= 1997 |pmid= 9130707 |doi= 10.1093/emboj/16.7.1620
*cite journal | author=Stein B, Yang MX, Young DB, "et al." |title=p38-2, a novel mitogen-activated protein kinase with distinct properties. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19509–17 |year= 1997 |pmid= 9235954 |doi=
*cite journal | author=Mo Y, Vaessen B, Johnston K, Marmorstein R |title=Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 201–12 |year= 1998 |pmid= 9734357 |doi=
*cite journal | author=Yates PR, Atherton GT, Deed RW, "et al." |title=Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. |journal=EMBO J. |volume=18 |issue= 4 |pages= 968–76 |year= 1999 |pmid= 10022839 |doi= 10.1093/emboj/18.4.968
*cite journal | author=Kamakura S, Moriguchi T, Nishida E |title=Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. |journal=J. Biol. Chem. |volume=274 |issue= 37 |pages= 26563–71 |year= 1999 |pmid= 10473620 |doi=
*cite journal | author=Chai Y, Chipitsyna G, Cui J, "et al." |title=c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. |journal=Oncogene |volume=20 |issue= 11 |pages= 1357–67 |year= 2001 |pmid= 11313879 |doi= 10.1038/sj.onc.1204256
*cite journal | author=Hassler M, Richmond TJ |title=The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3018–28 |year= 2001 |pmid= 11406578 |doi= 10.1093/emboj/20.12.3018
*cite journal | author=Mo Y, Ho W, Johnston K, Marmorstein R |title=Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. |journal=J. Mol. Biol. |volume=314 |issue= 3 |pages= 495–506 |year= 2002 |pmid= 11846562 |doi= 10.1006/jmbi.2001.5138
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

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