Myogenin


Myogenin
Myogenin (myogenic factor 4)
Identifiers
Symbols MYOG; MYF4; MYOGENIN; bHLHc3
External IDs OMIM159980 MGI97276 HomoloGene1854 GeneCards: MYOG Gene
RNA expression pattern
PBB GE MYOG 207282 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4656 17928
Ensembl ENSG00000122180 ENSMUSG00000026459
UniProt P15173 P12979
RefSeq (mRNA) NM_002479.4 NM_031189.2
RefSeq (protein) NP_002470.2 NP_112466.1
Location (UCSC) Chr 1:
203.05 – 203.06 Mb
Chr 1:
136.19 – 136.19 Mb
PubMed search [1] [2]

Myogenin (myogenic factor 4), also known as MYOG, is a gene.[1]

Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and Mrf4.

In mice, myogenin is essential for the development of functional skeletal muscle. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.

In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

Contents

Interactions

Myogenin has been shown to interact with POLR2C,[2] Sp1 transcription factor,[3] TCF3,[4][5] Serum response factor[3][6] and MDFI.[7]

References

  1. ^ "Entrez Gene: MYOG myogenin (myogenic factor 4)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4656. 
  2. ^ Corbi, Nicoletta; Di Padova Monica, De Angelis Roberta, Bruno Tiziana, Libri Valentina, Iezzi Simona, Floridi Aristide, Fanciulli Maurizio, Passananti Claudio (Oct. 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. (United States) 16 (12): 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009. 
  3. ^ a b Biesiada, E; Hamamori Y, Kedes L, Sartorelli V (Apr. 1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Mol. Cell. Biol. (UNITED STATES) 19 (4): 2577–84. ISSN 0270-7306. PMC 84050. PMID 10082523. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84050. 
  4. ^ Langlands, K; Yin X, Anand G, Prochownik E V (Aug. 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. (UNITED STATES) 272 (32): 19785–93. doi:10.1074/jbc.272.32.19785. ISSN 0021-9258. PMID 9242638. 
  5. ^ Chakraborty, T; Martin J F, Olson E N (Sep. 1992). "Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system". J. Biol. Chem. (UNITED STATES) 267 (25): 17498–501. ISSN 0021-9258. PMID 1325437. 
  6. ^ Groisman, R; Masutani H, Leibovitch M P, Robin P, Soudant I, Trouche D, Harel-Bellan A (Mar. 1996). "Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins". J. Biol. Chem. (UNITED STATES) 271 (9): 5258–64. doi:10.1074/jbc.271.9.5258. ISSN 0021-9258. PMID 8617811. 
  7. ^ Chen, C M; Kraut N, Groudine M, Weintraub H (Sep. 1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell (UNITED STATES) 86 (5): 731–41. doi:10.1016/S0092-8674(00)80148-8. ISSN 0092-8674. PMID 8797820. 

Further reading

External links



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