GATA binding protein 5, also known as GATA5, is a human gene.cite web | title = Entrez Gene: GATA5 GATA binding protein 5| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.cite web | title = Entrez Gene: GATA5 GATA binding protein 5| url =| accessdate = ]

ee also

* GATA transcription factor


Further reading

citations =
*cite journal | author=Gao X, Sedgwick T, Shi YB, Evans T |title=Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2901–11 |year= 1998 |pmid= 9566909 |doi=
*cite journal | author=Kakita T, Hasegawa K, Morimoto T, "et al." |title=p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34096–102 |year= 1999 |pmid= 10567378 |doi=
*cite journal | author=Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ |title=Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G69–84 |year= 2001 |pmid= 11408257 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=van Wering HM, Huibregtse IL, van der Zwan SM, "et al." |title=Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27659–67 |year= 2002 |pmid= 12011060 |doi= 10.1074/jbc.M203645200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Benchabane H, Wrana JL |title=GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6646–61 |year= 2003 |pmid= 12944489 |doi=
*cite journal | author=Akiyama Y, Watkins N, Suzuki H, "et al." |title=GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8429–39 |year= 2003 |pmid= 14612389 |doi=
*cite journal | author=Divine JK, Staloch LJ, Haveri H, "et al." |title=GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=287 |issue= 5 |pages= G1086–99 |year= 2004 |pmid= 14715527 |doi= 10.1152/ajpgi.00421.2003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Guo M, Akiyama Y, House MG, "et al." |title=Hypermethylation of the GATA genes in lung cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 23 |pages= 7917–24 |year= 2005 |pmid= 15585625 |doi= 10.1158/1078-0432.CCR-04-1140
*cite journal | author=Wakana K, Akiyama Y, Aso T, Yuasa Y |title=Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. |journal=Cancer Lett. |volume=241 |issue= 2 |pages= 281–8 |year= 2006 |pmid= 16337738 |doi= 10.1016/j.canlet.2005.10.039
*cite journal | author=Guo M, House MG, Akiyama Y, "et al." |title=Hypermethylation of the GATA gene family in esophageal cancer. |journal=Int. J. Cancer |volume=119 |issue= 9 |pages= 2078–83 |year= 2006 |pmid= 16823849 |doi= 10.1002/ijc.22092

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • GATA transcription factor — GATA transcription factors are a family of transcription factors characterized by their ability to bind to the sequence GATA .cite journal |author=Ko LJ, Engel JD |title=DNA binding specificities of the GATA transcription factor family… …   Wikipedia

  • GATA — Los factores de transcripción GATA son una familia de proteínas caracterizadas por su capacidad de unirse a la secuencia de ADN GATA (donde G = Guanina, A = Adenina y T = Timina).[1] Proteínas pertenecientes a la familia GATA GATA1 (gen GATA1)… …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.