Structure specific recognition protein 1

Structure specific recognition protein 1

Structure specific recognition protein 1, also known as SSRP1, is a human protein.cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Bruhn SL, Pil PM, Essigmann JM, "et al." |title=Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2307–11 |year= 1992 |pmid= 1372440 |doi=
*cite journal | author=Toney JH, Donahue BA, Kellett PJ, "et al." |title=Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II) |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8328–32 |year= 1989 |pmid= 2530581 |doi=
*cite journal | author=Nagulapalli S, Pongubala JM, Atchison ML |title=Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). |journal=J. Immunol. |volume=155 |issue= 9 |pages= 4330–8 |year= 1995 |pmid= 7594592 |doi=
*cite journal | author=Orphanides G, LeRoy G, Chang CH, "et al." |title=FACT, a factor that facilitates transcript elongation through nucleosomes. |journal=Cell |volume=92 |issue= 1 |pages= 105–16 |year= 1998 |pmid= 9489704 |doi=
*cite journal | author=Dyer MA, Hayes PJ, Baron MH |title=The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2617–28 |year= 1998 |pmid= 9566881 |doi=
*cite journal | author=LeRoy G, Orphanides G, Lane WS, Reinberg D |title=Requirement of RSF and FACT for transcription of chromatin templates in vitro. |journal=Science |volume=282 |issue= 5395 |pages= 1900–4 |year= 1998 |pmid= 9836642 |doi=
*cite journal | author=Kelley DE, Stokes DG, Perry RP |title=CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. |journal=Chromosoma |volume=108 |issue= 1 |pages= 10–25 |year= 1999 |pmid= 10199952 |doi=
*cite journal | author=Spencer JA, Baron MH, Olson EN |title=Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15686–93 |year= 1999 |pmid= 10336466 |doi=
*cite journal | author=Orphanides G, Wu WH, Lane WS, "et al." |title=The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. |journal=Nature |volume=400 |issue= 6741 |pages= 284–8 |year= 1999 |pmid= 10421373 |doi= 10.1038/22350
*cite journal | author=Wada T, Orphanides G, Hasegawa J, "et al." |title=FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. |journal=Mol. Cell |volume=5 |issue= 6 |pages= 1067–72 |year= 2000 |pmid= 10912001 |doi=
*cite journal | author=Keller DM, Zeng X, Wang Y, "et al." |title=A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. |journal=Mol. Cell |volume=7 |issue= 2 |pages= 283–92 |year= 2001 |pmid= 11239457 |doi=
*cite journal | author=Yarnell AT, Oh S, Reinberg D, Lippard SJ |title=Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25736–41 |year= 2001 |pmid= 11344167 |doi= 10.1074/jbc.M101208200
*cite journal | author=Santoro P, De Andrea M, Migliaretti G, "et al." |title=High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. |journal=J. Rheumatol. |volume=29 |issue= 1 |pages= 90–3 |year= 2002 |pmid= 11824977 |doi=
*cite journal | author=Roig J, Mikhailov A, Belham C, Avruch J |title=Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. |journal=Genes Dev. |volume=16 |issue= 13 |pages= 1640–58 |year= 2002 |pmid= 12101123 |doi= 10.1101/gad.972202
*cite journal | author=Zeng SX, Dai MS, Keller DM, Lu H |title=SSRP1 functions as a co-activator of the transcriptional activator p63. |journal=EMBO J. |volume=21 |issue= 20 |pages= 5487–97 |year= 2002 |pmid= 12374749 |doi=
*cite journal | author=Keller DM, Lu H |title=p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50206–13 |year= 2003 |pmid= 12393879 |doi= 10.1074/jbc.M209820200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Belotserkovskaya R, Oh S, Bondarenko VA, "et al." |title=FACT facilitates transcription-dependent nucleosome alteration. |journal=Science |volume=301 |issue= 5636 |pages= 1090–3 |year= 2003 |pmid= 12934006 |doi= 10.1126/science.1085703
*cite journal | author=Li J, Hawkins IC, Harvey CD, "et al." |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=
*cite journal | author=Tan BC, Lee SC |title=Nek9, a novel FACT-associated protein, modulates interphase progression. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9321–30 |year= 2004 |pmid= 14660563 |doi= 10.1074/jbc.M311477200

External links


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