CDX2


CDX2

Caudal type homeobox transcription factor 2, also known as CDX2, is a human gene.cite journal | author = German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI | title = Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13 | journal = Genomics | volume = 24 | issue = 2 | pages = 403–4 | year = 1994 | month = November | pmid = 7698771 | doi = 10.1006/geno.1994.1639 | url = | issn = ] The protein encoded by this gene is a homeobox transcription factor.

Function

Cdx2 is the gene that directs early embryogenesis in mice. It is required to form the placenta.cite journal | author = Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F | title = Cdx2 is essential for axial elongation in mouse development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 20 | pages = 7641–5 | year = 2004 | month = May | pmid = 15136723 | pmc = 419659 | doi = 10.1073/pnas.0401654101 | url = | issn = ]

Ectopic expression of CDX2 was reported more than 85% of the human patients with Acute myeloid leukemia (AML). Ectopic expression of Cdx2 in murine bome marrow induced AML in mice and upregulate Hox genes in bone marrow progenitors.cite journal | author = Rawat VP, Cusan M, Deshpande A, Hiddemann W, Quintanilla-Martinez L, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C | title = Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 3 | pages = 817–22 | year = 2004 | month = January | pmid = 14718672 | pmc = 321764 | doi = 10.1073/pnas.0305555101 | url = | issn = ] cite journal | author = Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJ, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, Gilliland DG, Fröhling S | title = The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis | journal = J. Clin. Invest. | volume = 117 | issue = 4 | pages = 1037–48 | year = 2007 | month = April | pmid = 17347684 | pmc = 1810574 | doi = 10.1172/JCI30182 | url = | issn = ] cite journal | author = Rawat VP, Cusan M, Deshpande A, Hiddemann W, Quintanilla-Martinez L, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C | title = Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 3 | pages = 817–22 | year = 2004 | month = January | pmid = 14718672 | pmc = 321764 | doi = 10.1073/pnas.0305555101 | url = | issn = ]

Biomarker for intestinal cancer

CDX2 is also used in diagnostic surgical pathology as a marker for gastrointestinal differentiation, especially colorectal.cite journal | author = Liu Q, Teh M, Ito K, Shah N, Ito Y, Yeoh KG | title = CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer | journal = Mod. Pathol. | volume = 20 | issue = 12 | pages = 1286–97 | year = 2007 | month = December | pmid = 17906616 | doi = 10.1038/modpathol.3800968 | url = | issn = ]

Possible use in stem cell research

This gene (or, more specifically, the equivalent gene in humans) has come up in the proposal by the President's Council on Bioethics, as a solution to the stem cell controversy.cite web | url = http://www.bioethics.gov/background/hurlbut.html | title = Altered Nuclear Transfer as a Morally Acceptable Means for the Procurement of Human Embryonic Stem Cells | author = Hurlbut WB | authorlink = | coauthors = | date = 2004 | format = | work = The President's Council on Bioethics | publisher = The White House of the United States of America | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-07-16] According to one of the plans put forth, by deactivating the gene, it would not be possible for a properly organized embryo to form, thus providing stem cells without requiring the destruction of an embryo.cite web | url = http://slate.msn.com/id/2110670/fr/rss/ | title = The creepy solution to the stem-cell debate | author = Saletan W | authorlink = | coauthors = | date = 2004-12-06 | format = | work = | publisher = Slate Magazine | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-07-16] Other genes that have been proposed for this purpose include Hnf4, which is required for gastrulation.cite journal | author = Hurlbut WB | title = Ethics and embryonic stem cell research: altered nuclear transfer as a way forward | journal = BioDrugs | volume = 21 | issue = 2 | pages = 79–83 | year = 2007 | pmid = 17402791 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=German MS, Wang J, Fernald AA, "et al." |title=Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13. |journal=Genomics |volume=24 |issue= 2 |pages= 403–4 |year= 1995 |pmid= 7698771 |doi= 10.1006/geno.1994.1639
*cite journal | author=Suh E, Chen L, Taylor J, Traber PG |title=A homeodomain protein related to caudal regulates intestine-specific gene transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 11 |pages= 7340–51 |year= 1994 |pmid= 7935448 |doi=
*cite journal | author=Inoue H, Riggs AC, Tanizawa Y, "et al." |title=Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene. |journal=Diabetes |volume=45 |issue= 6 |pages= 789–94 |year= 1996 |pmid= 8635654 |doi=
*cite journal | author=Mallo GV, Rechreche H, Frigerio JM, "et al." |title=Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. |journal=Int. J. Cancer |volume=74 |issue= 1 |pages= 35–44 |year= 1997 |pmid= 9036867 |doi=
*cite journal | author=Chawengsaksophak K, James R, Hammond VE, "et al." |title=Homeosis and intestinal tumours in Cdx2 mutant mice. |journal=Nature |volume=386 |issue= 6620 |pages= 84–7 |year= 1997 |pmid= 9052785 |doi= 10.1038/386084a0
*cite journal | author=Walters JR, Howard A, Rumble HE, "et al." |title=Differences in expression of homeobox transcription factors in proximal and distal human small intestine. |journal=Gastroenterology |volume=113 |issue= 2 |pages= 472–7 |year= 1997 |pmid= 9247466 |doi=
*cite journal | author=Drummond F, Putt W, Fox M, Edwards YH |title=Cloning and chromosome assignment of the human CDX2 gene. |journal=Ann. Hum. Genet. |volume=61 |issue= Pt 5 |pages= 393–400 |year= 1998 |pmid= 9459001 |doi= 10.1046/j.1469-1809.1997.6150393.x
*cite journal | author=Yamamoto H, Miyamoto K, Li B, "et al." |title=The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine. |journal=J. Bone Miner. Res. |volume=14 |issue= 2 |pages= 240–7 |year= 1999 |pmid= 9933478 |doi=
*cite journal | author=Lorentz O, Suh ER, Taylor JK, "et al." |title=CREB-binding [corrected] protein interacts with the homeodomain protein Cdx2 and enhances transcriptional activity. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7196–9 |year= 1999 |pmid= 10066780 |doi=
*cite journal | author=Hussain MA, Habener JF |title=Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 28950–7 |year= 1999 |pmid= 10506141 |doi=
*cite journal | author=Mitchelmore C, Troelsen JT, Spodsberg N, "et al." |title=Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene. |journal=Biochem. J. |volume=346 Pt 2 |issue= |pages= 529–35 |year= 2000 |pmid= 10677375 |doi=
*cite journal | author=Sivagnanasundaram S, Islam I, Talbot I, "et al." |title=The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis. |journal=Br. J. Cancer |volume=84 |issue= 2 |pages= 218–25 |year= 2001 |pmid= 11161380 |doi= 10.1054/bjoc.2000.1544
*cite journal | author=Rings EH, Boudreau F, Taylor JK, "et al." |title=Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. |journal=Gastroenterology |volume=121 |issue= 6 |pages= 1437–50 |year= 2001 |pmid= 11729123 |doi=
*cite journal | author=Hinoi T, Tani M, Lucas PC, "et al." |title=Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. |journal=Am. J. Pathol. |volume=159 |issue= 6 |pages= 2239–48 |year= 2001 |pmid= 11733373 |doi=
*cite journal | author=Mizoshita T, Inada K, Tsukamoto T, "et al." |title=Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach. |journal=Gastric Cancer |volume=4 |issue= 4 |pages= 185–91 |year= 2002 |pmid= 11846061 |doi=
*cite journal | author=Eda A, Osawa H, Yanaka I, "et al." |title=Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. |journal=J. Gastroenterol. |volume=37 |issue= 2 |pages= 94–100 |year= 2002 |pmid= 11871772 |doi=
*cite journal | author=Qualtrough D, Hinoi T, Fearon E, Paraskeva C |title=Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. |journal=Gut |volume=51 |issue= 2 |pages= 184–90 |year= 2002 |pmid= 12117877 |doi=
*cite journal | author=Moucadel V, Totaro MS, Dell CD, "et al." |title=The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 3 |pages= 607–15 |year= 2002 |pmid= 12270138 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Song BL, Qi W, Wang CH, "et al." |title=Preparation of an anti-Cdx-2 antibody for analysis of different species Cdx-2 binding to acat2 promoter. |journal=Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao |volume=35 |issue= 1 |pages= 6–12 |year= 2003 |pmid= 12518221 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • CDX1 — Caudal type homeobox transcription factor 1, also known as CDX1, is a human gene.cite web | title = Entrez Gene: CDX1 caudal type homeobox transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Old Europa Cafe discography — This is a discography for Old Europa Cafe records. Il Sogno Mediterraneo Di De Fabriek OECD 001 (1985) Manifesto Industriale Italiano Various Artist 4XCassette OEC 100 Aurora Ain Soph CD OECD 053 OECD 053 X (2003) A Silent Siege Deutsch Nepal CD… …   Wikipedia

  • Mouse models of colorectal and intestinal cancer — Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated or challenged with chemicals to develop malignancies in the gastrointestinal tract. These models enable researchers to… …   Wikipedia

  • CREB-binding protein — See also: p300 CBP coactivator family CREB binding protein PDB rendering based on 1f81 …   Wikipedia

  • Cdx-Proteine — Caudale Homöobox Proteine (Cdx) sind eine Familie von Proteinen, die in mehrzelligen Tieren die räumliche Entwicklung des caudalen (hinteren) Bereichs des Embryos steuern. Sie leisten diese Funktion durch ihre Eigenschaft als… …   Deutsch Wikipedia

  • Mammalian embryogenesis — is the process of cell division and cellular differentiation during early prenatal development which leads to the development of a mammalian embryo. Contents 1 Difference from human embryogenesis 1.1 Humans 1.2 …   Wikipedia

  • Blastocyst — Infobox Embryology Name = Blastocyte Latin = GraySubject = GrayPage = Caption = Caption2 = System = CarnegieStage = 3 Days = 5 Precursor = GivesRiseTo = MeshName = Blastocyst MeshNumber = A16.254.085 DorlandsPre = b 14 DorlandsSuf = 12187695 The… …   Wikipedia

  • Bleeding Through — performs at Alpine Valley Music Theatre as part of the Ozzfest in 2006 Background information …   Wikipedia

  • Kindertotenlieder — ( Songs on the Death of Children ) is a song cycle for voice and orchestra by Gustav Mahler. The words of the songs are poems by Friedrich Rückert.The original Kindertotenlieder were a group of 425 poems written by Rückert in 1833–34 in an… …   Wikipedia

  • Retraction — A retraction is a public statement, either in print, or by verbal statement that is made to correct a previously made statement that was incorrect, invalid, or in error. The intent of a public retraction is to correct any incorrect… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.