GATA binding protein 4, also known as GATA4, is a human gene.

section_title =
summary_text = This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.cite web | title = Entrez Gene: GATA4 GATA binding protein 4| url =| accessdate = ]

ee also

* GATA transcription factor


Further reading

citations =
*cite journal | author=Evans T, Reitman M, Felsenfeld G |title=An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 16 |pages= 5976–80 |year= 1988 |pmid= 3413070 |doi=
*cite journal | author=White RA, Dowler LL, Pasztor LM, "et al." |title=Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). |journal=Genomics |volume=27 |issue= 1 |pages= 20–6 |year= 1995 |pmid= 7665171 |doi= 10.1006/geno.1995.1003
*cite journal | author=Huang WY, Cukerman E, Liew CC |title=Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA. |journal=Gene |volume=155 |issue= 2 |pages= 219–23 |year= 1995 |pmid= 7721094 |doi=
*cite journal | author=Yamagata T, Nishida J, Sakai R, "et al." |title=Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3830–9 |year= 1995 |pmid= 7791790 |doi=
*cite journal | author=Molkentin JD, Kalvakolanu DV, Markham BE |title=Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. |journal=Mol. Cell. Biol. |volume=14 |issue= 7 |pages= 4947–57 |year= 1994 |pmid= 8007990 |doi=
*cite journal | author=Arceci RJ, King AA, Simon MC, "et al." |title=Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. |journal=Mol. Cell. Biol. |volume=13 |issue= 4 |pages= 2235–46 |year= 1993 |pmid= 8455608 |doi=
*cite journal | author=Huang WY, Heng HH, Liew CC |title=Assignment of the human GATA4 gene to 8p23.1-->p22 using fluorescence in situ hybridization analysis. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 217–8 |year= 1997 |pmid= 8978781 |doi=
*cite journal | author=Herzig TC, Jobe SM, Aoki H, "et al." |title=Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7543–8 |year= 1997 |pmid= 9207128 |doi=
*cite journal | author=Durocher D, Charron F, Warren R, "et al." |title=The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. |journal=EMBO J. |volume=16 |issue= 18 |pages= 5687–96 |year= 1997 |pmid= 9312027 |doi= 10.1093/emboj/16.18.5687
*cite journal | author=Molkentin JD, Lu JR, Antos CL, "et al." |title=A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. |journal=Cell |volume=93 |issue= 2 |pages= 215–28 |year= 1998 |pmid= 9568714 |doi=
*cite journal | author=Svensson EC, Tufts RL, Polk CE, Leiden JM |title=Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 3 |pages= 956–61 |year= 1999 |pmid= 9927675 |doi=
*cite journal | author=Tremblay JJ, Viger RS |title=Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1. |journal=Mol. Endocrinol. |volume=13 |issue= 8 |pages= 1388–401 |year= 1999 |pmid= 10446911 |doi=
*cite journal | author=Lin L, Aggarwal S, Glover TW, "et al." |title=A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene. |journal=Cancer Res. |volume=60 |issue= 5 |pages= 1341–7 |year= 2000 |pmid= 10728696 |doi=
*cite journal | author=Morin S, Charron F, Robitaille L, Nemer M |title=GATA-dependent recruitment of MEF2 proteins to target promoters. |journal=EMBO J. |volume=19 |issue= 9 |pages= 2046–55 |year= 2000 |pmid= 10790371 |doi= 10.1093/emboj/19.9.2046
*cite journal | author=Zhu W, Shiojima I, Hiroi Y, "et al." |title=Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35291–6 |year= 2001 |pmid= 10948187 |doi= 10.1074/jbc.M000525200
*cite journal | author=Belaguli NS, Sepulveda JL, Nigam V, "et al." |title=Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7550–8 |year= 2000 |pmid= 11003651 |doi=
*cite journal | author=Morin S, Paradis P, Aries A, Nemer M |title=Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1036–44 |year= 2001 |pmid= 11158291 |doi= 10.1128/MCB.21.4.1036-1044.2001
*cite journal | author=Crispino JD, Lodish MB, Thurberg BL, "et al." |title=Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. |journal=Genes Dev. |volume=15 |issue= 7 |pages= 839–44 |year= 2001 |pmid= 11297508 |doi= 10.1101/gad.875201
*cite journal | author=Dai YS, Markham BE |title=p300 Functions as a coactivator of transcription factor GATA-4. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37178–85 |year= 2001 |pmid= 11481322 |doi= 10.1074/jbc.M103731200
*cite journal | author=Liang Q, Wiese RJ, Bueno OF, "et al." |title=The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7460–9 |year= 2001 |pmid= 11585926 |doi= 10.1128/MCB.21.21.7460-7469.2001

External links


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