AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a human gene.cite web | title = Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.cite web | title = Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Defeo-Jones D, Huang PS, Jones RE, "et al." |title=Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. |journal=Nature |volume=352 |issue= 6332 |pages= 251–4 |year= 1991 |pmid= 1857421 |doi= 10.1038/352251a0
*cite journal | author=Fattaey AR, Helin K, Dembski MS, "et al." |title=Characterization of the retinoblastoma binding proteins RBP1 and RBP2. |journal=Oncogene |volume=8 |issue= 11 |pages= 3149–56 |year= 1993 |pmid= 8414517 |doi=
*cite journal | author=Otterson GA, Kratzke RA, Lin AY, "et al." |title=Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. |journal=Oncogene |volume=8 |issue= 4 |pages= 949–57 |year= 1993 |pmid= 8455946 |doi=
*cite journal | author=Margottin F, Bour SP, Durand H, "et al." |title=A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. |journal=Mol. Cell |volume=1 |issue= 4 |pages= 565–74 |year= 1998 |pmid= 9660940 |doi=
*cite journal | author=Lai A, Marcellus RC, Corbeil HB, Branton PE |title=RBP1 induces growth arrest by repression of E2F-dependent transcription. |journal=Oncogene |volume=18 |issue= 12 |pages= 2091–100 |year= 1999 |pmid= 10321733 |doi= 10.1038/sj.onc.1202520
*cite journal | author=Cao J, Gao T, Giuliano AE, Irie RF |title=Recognition of an epitope of a breast cancer antigen by human antibody. |journal=Breast Cancer Res. Treat. |volume=53 |issue= 3 |pages= 279–90 |year= 1999 |pmid= 10369074 |doi=
*cite journal | author=Lai A, Lee JM, Yang WM, "et al." |title=RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6632–41 |year= 2000 |pmid= 10490602 |doi=
*cite journal | author=Lai A, Kennedy BK, Barbie DA, "et al." |title=RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. |journal=Mol. Cell. Biol. |volume=21 |issue= 8 |pages= 2918–32 |year= 2001 |pmid= 11283269 |doi= 10.1128/MCB.21.8.2918-2932.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fleischer TC, Yun UJ, Ayer DE |title=Identification and characterization of three new components of the mSin3A corepressor complex. |journal=Mol. Cell. Biol. |volume=23 |issue= 10 |pages= 3456–67 |year= 2003 |pmid= 12724404 |doi=
*cite journal | author=Meehan WJ, Samant RS, Hopper JE, "et al." |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1562–9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Monroe DG, Secreto FJ, Hawse JR, "et al." |title=Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28596–604 |year= 2006 |pmid= 16873370 |doi= 10.1074/jbc.M605226200

External links


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