ETV6 is an oncogene.

section_title =
summary_text = This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [cite web | title = Entrez Gene: ETV6 ets variant gene 6 (TEL oncogene)| url =| accessdate = ]

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Further reading

citations =
*cite journal | author=Keung YK, Beaty M, Steward W, "et al." |title=Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature. |journal=Cancer Genet. Cytogenet. |volume=138 |issue= 2 |pages= 139–42 |year= 2003 |pmid= 12505259 |doi=
*cite journal | author=Fainstein E, Einat M, Gokkel E, "et al." |title=Nucleotide sequence analysis of human abl and bcr-abl cDNAs. |journal=Oncogene |volume=4 |issue= 12 |pages= 1477–81 |year= 1990 |pmid= 2687768 |doi=
*cite journal | author=Buijs A, Sherr S, van Baal S, "et al." |title=Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. |journal=Oncogene |volume=10 |issue= 8 |pages= 1511–9 |year= 1995 |pmid= 7731705 |doi=
*cite journal | author=Golub TR, Barker GF, Bohlander SK, "et al." |title=Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 11 |pages= 4917–21 |year= 1995 |pmid= 7761424 |doi=
*cite journal | author=Romana SP, Mauchauffé M, Le Coniat M, "et al." |title=The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. |journal=Blood |volume=85 |issue= 12 |pages= 3662–70 |year= 1995 |pmid= 7780150 |doi=
*cite journal | author=Papadopoulos P, Ridge SA, Boucher CA, "et al." |title=The novel activation of ABL by fusion to an ets-related gene, TEL. |journal=Cancer Res. |volume=55 |issue= 1 |pages= 34–8 |year= 1995 |pmid= 7805037 |doi=
*cite journal | author=Golub TR, Barker GF, Lovett M, Gilliland DG |title=Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. |journal=Cell |volume=77 |issue= 2 |pages= 307–16 |year= 1994 |pmid= 8168137 |doi=
*cite journal | author=Wlodarska I, Baens M, Peeters P, "et al." |title=Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case. |journal=Cancer Res. |volume=56 |issue= 11 |pages= 2655–61 |year= 1996 |pmid= 8653712 |doi=
*cite journal | author=Baens M, Peeters P, Guo C, "et al." |title=Genomic organization of TEL: the human ETS-variant gene 6. |journal=Genome Res. |volume=6 |issue= 5 |pages= 404–13 |year= 1996 |pmid= 8743990 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Andreasson P, Johansson B, Arheden K, "et al." |title=Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. |journal=Genes Chromosomes Cancer |volume=19 |issue= 2 |pages= 77–83 |year= 1997 |pmid= 9171997 |doi=
*cite journal | author=Lacronique V, Boureux A, Valle VD, "et al." |title=A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. |journal=Science |volume=278 |issue= 5341 |pages= 1309–12 |year= 1997 |pmid= 9360930 |doi=
*cite journal | author=Knezevich SR, McFadden DE, Tao W, "et al." |title=A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. |journal=Nat. Genet. |volume=18 |issue= 2 |pages= 184–7 |year= 1998 |pmid= 9462753 |doi= 10.1038/ng0298-184
*cite journal | author=Kwiatkowski BA, Bastian LS, Bauer TR, "et al." |title=The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17525–30 |year= 1998 |pmid= 9651344 |doi=
*cite journal | author=Hannemann JR, McManus DM, Kabarowski JH, Wiedemann LM |title=Haemopoietic transformation by the TEL/ABL oncogene. |journal=Br. J. Haematol. |volume=102 |issue= 2 |pages= 475–85 |year= 1998 |pmid= 9695962 |doi=
*cite journal | author=Chakrabarti SR, Sood R, Ganguly S, "et al." |title=Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7467–72 |year= 1999 |pmid= 10377438 |doi=
*cite journal | author=Cools J, Bilhou-Nabera C, Wlodarska I, "et al." |title=Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). |journal=Blood |volume=94 |issue= 5 |pages= 1820–4 |year= 1999 |pmid= 10477709 |doi=
*cite journal | author=Yagasaki F, Jinnai I, Yoshida S, "et al." |title=Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). |journal=Genes Chromosomes Cancer |volume=26 |issue= 3 |pages= 192–202 |year= 2000 |pmid= 10502316 |doi=
*cite journal | author=Wai DH, Knezevich SR, Lucas T, "et al." |title=The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. |journal=Oncogene |volume=19 |issue= 7 |pages= 906–15 |year= 2000 |pmid= 10702799 |doi= 10.1038/sj.onc.1203396

External links


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