Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

section_title =
summary_text = IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.cite web | title = Entrez Gene: IRF7 interferon regulatory factor 7| url =| accessdate = ]

ee also

* Interferon regulatory factors


Further reading

citations =
*cite journal | author=Pitha PM, Au WC, Lowther W, "et al." |title=Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 651–8 |year= 1999 |pmid= 9865487 |doi=
*cite journal | author=Zhang L, Pagano JS |title=Structure and function of IRF-7. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 1 |pages= 95–101 |year= 2002 |pmid= 11846980 |doi= 10.1089/107999002753452700
*cite journal | author=Zhang L, Pagano JS |title=IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 5748–57 |year= 1997 |pmid= 9315633 |doi=
*cite journal | author=Wathelet MG, Lin CH, Parekh BS, "et al." |title=Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. |journal=Mol. Cell |volume=1 |issue= 4 |pages= 507–18 |year= 1998 |pmid= 9660935 |doi=
*cite journal | author=Au WC, Moore PA, LaFleur DW, "et al." |title=Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 29210–7 |year= 1998 |pmid= 9786932 |doi=
*cite journal | author=Lu R, Au WC, Yeow WS, "et al." |title=Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31805–12 |year= 2000 |pmid= 10924517 |doi= 10.1074/jbc.M005288200
*cite journal | author=Paris MJ, Williams BR |title=Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5. |journal=Genomics |volume=69 |issue= 2 |pages= 196–202 |year= 2001 |pmid= 11031102 |doi= 10.1006/geno.2000.6339
*cite journal | author=Marié I, Smith E, Prakash A, Levy DE |title=Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8803–14 |year= 2000 |pmid= 11073981 |doi=
*cite journal | author=Smith EJ, Marié I, Prakash A, "et al." |title=IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8951–7 |year= 2001 |pmid= 11124948 |doi= 10.1074/jbc.M008717200
*cite journal | author=Au WC, Yeow WS, Pitha PM |title=Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. |journal=Virology |volume=280 |issue= 2 |pages= 273–82 |year= 2001 |pmid= 11162841 |doi= 10.1006/viro.2000.0782
*cite journal | author=Lu R, Moore PA, Pitha PM |title=Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16592–8 |year= 2002 |pmid= 11877397 |doi= 10.1074/jbc.M111440200
*cite journal | author=Morin P, Bragança J, Bandu MT, "et al." |title=Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. |journal=J. Mol. Biol. |volume=316 |issue= 5 |pages= 1009–22 |year= 2002 |pmid= 11884139 |doi= 10.1006/jmbi.2001.5401
*cite journal | author=Caillaud A, Prakash A, Smith E, "et al." |title=Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49417–21 |year= 2003 |pmid= 12374802 |doi= 10.1074/jbc.M207484200
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822
*cite journal | author=Yang H, Lin CH, Ma G, "et al." |title=Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15495–504 |year= 2003 |pmid= 12604599 |doi= 10.1074/jbc.M212940200
*cite journal | author=Ning S, Hahn AM, Huye LE, Pagano JS |title=Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. |journal=J. Virol. |volume=77 |issue= 17 |pages= 9359–68 |year= 2003 |pmid= 12915551 |doi=
*cite journal | author=Fitzgerald KA, Rowe DC, Barnes BJ, "et al." |title=LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. |journal=J. Exp. Med. |volume=198 |issue= 7 |pages= 1043–55 |year= 2003 |pmid= 14517278 |doi= 10.1084/jem.20031023
*cite journal | author=Lin R, Noyce RS, Collins SE, "et al." |title=The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes. |journal=J. Virol. |volume=78 |issue= 4 |pages= 1675–84 |year= 2004 |pmid= 14747533 |doi=

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