Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, also known as ID1, is a human gene.

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein| url =| accessdate = ]

See also

* Inhibitor of DNA-binding protein


Further reading

citations =
*cite journal | author=Zhu W, Dahmen J, Bulfone A, "et al." |title=Id gene expression during development and molecular cloning of the human Id-1 gene. |journal=Brain Res. Mol. Brain Res. |volume=30 |issue= 2 |pages= 312–26 |year= 1995 |pmid= 7637581 |doi=
*cite journal | author=Deed RW, Jasiok M, Norton JD |title=Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 1 |pages= 160–2 |year= 1994 |pmid= 8086456 |doi=
*cite journal | author=Hara E, Yamaguchi T, Nojima H, "et al." |title=Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2139–45 |year= 1994 |pmid= 8294468 |doi=
*cite journal | author=Mathew S, Chen W, Murty VV, "et al." |title=Chromosomal assignment of human ID1 and ID2 genes. |journal=Genomics |volume=30 |issue= 2 |pages= 385–7 |year= 1996 |pmid= 8586447 |doi= 10.1006/geno.1995.0037
*cite journal | author=Nehlin JO, Hara E, Kuo WL, "et al." |title=Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 3 |pages= 628–34 |year= 1997 |pmid= 9070860 |doi= 10.1006/bbrc.1997.6152
*cite journal | author=Anand G, Yin X, Shahidi AK, "et al." |title=Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19140–51 |year= 1997 |pmid= 9235903 |doi=
*cite journal | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785–93 |year= 1997 |pmid= 9242638 |doi=
*cite journal | author=Yates PR, Atherton GT, Deed RW, "et al." |title=Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. |journal=EMBO J. |volume=18 |issue= 4 |pages= 968–76 |year= 1999 |pmid= 10022839 |doi= 10.1093/emboj/18.4.968
*cite journal | author=Outinen PA, Sood SK, Pfeifer SI, "et al." |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=
*cite journal | author=Langlands K, Down GA, Kealey T |title=Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 5929–33 |year= 2000 |pmid= 11085505 |doi=
*cite journal | author=Ohtani N, Zebedee Z, Huot TJ, "et al." |title=Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. |journal=Nature |volume=409 |issue= 6823 |pages= 1067–70 |year= 2001 |pmid= 11234019 |doi= 10.1038/35059131
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101
*cite journal | author=Korchynskyi O, ten Dijke P |title=Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4883–91 |year= 2002 |pmid= 11729207 |doi= 10.1074/jbc.M111023200
*cite journal | author=Jögi A, Persson P, Grynfeld A, "et al." |title=Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9118–26 |year= 2002 |pmid= 11756408 |doi= 10.1074/jbc.M107713200
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Singh J, Murata K, Itahana Y, Desprez PY |title=Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex. |journal=Oncogene |volume=21 |issue= 12 |pages= 1812–22 |year= 2002 |pmid= 11896613 |doi= 10.1038/sj.onc.1205252
*cite journal | author=Liu CJ, Ding B, Wang H, Lengyel P |title=The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2893–905 |year= 2002 |pmid= 11940648 |doi=
*cite journal | author=Ouyang XS, Wang X, Ling MT, "et al." |title=Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway. |journal=Carcinogenesis |volume=23 |issue= 5 |pages= 721–5 |year= 2002 |pmid= 12016143 |doi=
*cite journal | author=Ling MT, Wang X, Tsao SW, Wong YC |title=Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells. |journal=Biochim. Biophys. Acta |volume=1570 |issue= 3 |pages= 145–52 |year= 2002 |pmid= 12020803 |doi=
*cite journal | author=Wang X, Xu K, Ling MT, "et al." |title=Evidence of increased Id-1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells. |journal=Mol. Carcinog. |volume=35 |issue= 1 |pages= 42–9 |year= 2002 |pmid= 12203366 |doi= 10.1002/mc.10072

External links


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