JARID2


JARID2

Jumonji, AT rich interactive domain 2, also known as JARID2, is a human gene.cite web | title = Entrez Gene: JARID2 jumonji, AT rich interactive domain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3720| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein.cite web | title = Entrez Gene: JARID2 jumonji, AT rich interactive domain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3720| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bergé-Lefranc JL, Jay P, Massacrier A, "et al." |title=Characterization of the human jumonji gene. |journal=Hum. Mol. Genet. |volume=5 |issue= 10 |pages= 1637–41 |year= 1997 |pmid= 8894700 |doi=
*cite journal | author=Lee Y, Song AJ, Baker R, "et al." |title=Jumonji, a nuclear protein that is necessary for normal heart development. |journal=Circ. Res. |volume=86 |issue= 9 |pages= 932–8 |year= 2000 |pmid= 10807864 |doi=
*cite journal | author=Toyoda M, Kojima M, Takeuchi T |title=Jumonji is a nuclear protein that participates in the negative regulation of cell growth. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 332–6 |year= 2000 |pmid= 10913339 |doi= 10.1006/bbrc.2000.3138
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kim TG, Kraus JC, Chen J, Lee Y |title=JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42247–55 |year= 2004 |pmid= 12890668 |doi= 10.1074/jbc.M307386200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Volcik KA, Zhu H, Finnell RH, "et al." |title=Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects. |journal=Am. J. Med. Genet. A |volume=126 |issue= 2 |pages= 215–7 |year= 2004 |pmid= 15057990 |doi= 10.1002/ajmg.a.20574
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kim TG, Chen J, Sadoshima J, Lee Y |title=Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. |journal=Mol. Cell. Biol. |volume=24 |issue= 23 |pages= 10151–60 |year= 2005 |pmid= 15542826 |doi= 10.1128/MCB.24.23.10151-10160.2004
*cite journal | author=Pedrosa E, Ye K, Nolan KA, "et al." |title=Positive association of schizophrenia to JARID2 gene. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 1 |pages= 45–51 |year= 2007 |pmid= 16967465 |doi= 10.1002/ajmg.b.30386

External links

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PBB_Controls
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