STAT2


STAT2

Signal transducer and activator of transcription 2, 113kDa, also known as STAT2, is a human gene.cite web | title = Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6773| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.cite web | title = Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6773| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cebulla CM, Miller DM, Sedmak DD |title=Viral inhibition of interferon signal transduction. |journal=Intervirology |volume=42 |issue= 5-6 |pages= 325–30 |year= 2000 |pmid= 10702714 |doi=
*cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1–24 |year= 2002 |pmid= 12039028 |doi=
*cite journal | author=Fu XY, Schindler C, Improta T, "et al." |title=The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 16 |pages= 7840–3 |year= 1992 |pmid= 1502204 |doi=
*cite journal | author=Uddin S, Chamdin A, Platanias LC |title=Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. |journal=J. Biol. Chem. |volume=270 |issue= 42 |pages= 24627–30 |year= 1995 |pmid= 7559568 |doi=
*cite journal | author=Marrero MB, Schieffer B, Paxton WG, "et al." |title=Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. |journal=Nature |volume=375 |issue= 6528 |pages= 247–50 |year= 1995 |pmid= 7746328 |doi= 10.1038/375247a0
*cite journal | author=Yan R, Qureshi S, Zhong Z, "et al." |title=The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. |journal=Nucleic Acids Res. |volume=23 |issue= 3 |pages= 459–63 |year= 1995 |pmid= 7885841 |doi=
*cite journal | author=Sugiyama T, Nishio Y, Kishimoto T, Akira S |title=Identification of alternative splicing form of Stat2. |journal=FEBS Lett. |volume=381 |issue= 3 |pages= 191–4 |year= 1996 |pmid= 8601453 |doi=
*cite journal | author=Yan H, Krishnan K, Greenlund AC, "et al." |title=Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1064–74 |year= 1996 |pmid= 8605876 |doi=
*cite journal | author=Gupta S, Yan H, Wong LH, "et al." |title=The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1075–84 |year= 1996 |pmid= 8605877 |doi=
*cite journal | author=Li X, Leung S, Qureshi S, "et al." |title=Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5790–4 |year= 1996 |pmid= 8621447 |doi=
*cite journal | author=Bhattacharya S, Eckner R, Grossman S, "et al." |title=Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. |journal=Nature |volume=383 |issue= 6598 |pages= 344–7 |year= 1996 |pmid= 8848048 |doi= 10.1038/383344a0
*cite journal | author=Horvath CM, Stark GR, Kerr IM, Darnell JE |title=Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6957–64 |year= 1997 |pmid= 8943351 |doi=
*cite journal | author=Bluyssen HA, Levy DE |title=Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4600–5 |year= 1997 |pmid= 9020188 |doi=
*cite journal | author=Li X, Leung S, Kerr IM, Stark GR |title=Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 2048–56 |year= 1997 |pmid= 9121453 |doi=
*cite journal | author=Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC |title=Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 20070–6 |year= 1997 |pmid= 9242679 |doi=
*cite journal | author=Mowen K, David M |title=Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30073–6 |year= 1998 |pmid= 9804758 |doi=
*cite journal | author=Dumler I, Kopmann A, Wagner K, "et al." |title=Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24059–65 |year= 1999 |pmid= 10446176 |doi=
*cite journal | author=Paulson M, Pisharody S, Pan L, "et al." |title=Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25343–9 |year= 1999 |pmid= 10464260 |doi=
*cite journal | author=Gupta S, Jiang M, Pernis AB |title=IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. |journal=J. Immunol. |volume=163 |issue= 7 |pages= 3834–41 |year= 1999 |pmid= 10490982 |doi=
*cite journal | author=Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, "et al." |title=The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. |journal=FASEB J. |volume=13 |issue= 13 |pages= 1699–710 |year= 1999 |pmid= 10506573 |doi=

External links

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