NEUROD1


NEUROD1
Neurogenic differentiation 1
Identifiers
Symbols NEUROD1; BETA2; BHF-1; MODY6; NEUROD; bHLHa3
External IDs OMIM601724 MGI1339708 HomoloGene1871 GeneCards: NEUROD1 Gene
RNA expression pattern
PBB GE NEUROD1 206282 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4760 18012
Ensembl ENSG00000162992 ENSMUSG00000034701
UniProt Q13562 P70449
RefSeq (mRNA) NM_002500.3 NM_010894.2
RefSeq (protein) NP_002491.2 NP_035024.1
Location (UCSC) Chr 2:
182.54 – 182.55 Mb
Chr 2:
79.29 – 79.3 Mb
PubMed search [1] [2]

Neurogenic differentiation 1 (NeuroD1), also called β2[1] is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.

It is a member of the NeuroD family of basic-helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.[2]


Contents

Interactions

NEUROD1 has been shown to interact with MAP3K10,[3] MAFA[4] and Cyclin D1.[5]

References

  1. ^ Poulin G, Turgeon B, Drouin J (November 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Mol. Cell. Biol. 17 (11): 6673–82. PMC 232521. PMID 9343431. http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=9343431. 
  2. ^ "Entrez Gene: NEUROD1 neurogenic differentiation 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4760. 
  3. ^ Marcora, Edoardo; Gowan Katherine, Lee Jacqueline E (Aug. 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (16): 9578–83. doi:10.1073/pnas.1133382100. ISSN 0027-8424. PMC 170960. PMID 12881483. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=170960. 
  4. ^ Zhao, Li; Guo Min, Matsuoka Taka-Aki, Hagman Derek K, Parazzoli Susan D, Poitout Vincent, Stein Roland (Mar. 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". J. Biol. Chem. (United States) 280 (12): 11887–94. doi:10.1074/jbc.M409475200. ISSN 0021-9258. PMID 15665000. 
  5. ^ Ratineau, Christelle; Petry Mary W, Mutoh Hiroyuki, Leiter Andrew B (Mar. 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD". J. Biol. Chem. (United States) 277 (11): 8847–53. doi:10.1074/jbc.M110747200. ISSN 0021-9258. PMID 11788592. 

Further reading

  • Fajans SS, Bell GI, Polonsky KS (2001). "Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young". N. Engl. J. Med. 345 (13): 971–80. doi:10.1056/NEJMra002168. PMID 11575290. 
  • Cho JH, Tsai MJ (2004). "The role of BETA2/NeuroD1 in the development of the nervous system". Mol. Neurobiol. 30 (1): 35–47. doi:10.1385/MN:30:1:035. PMID 15247487. 
  • Chae JH, Stein GH, Lee JE (2005). "NeuroD: the predicted and the surprising". Mol. Cells 18 (3): 271–88. PMID 15650322. 
  • Tamimi R, Steingrimsson E, Copeland NG, et al. (1996). "The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2". Genomics 34 (3): 418–21. doi:10.1006/geno.1996.0306. PMID 8786144. 
  • Yokoyama M, Nishi Y, Miyamoto Y, et al. (1997). "Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum". Brain Res. Mol. Brain Res. 42 (1): 135–9. doi:10.1016/S0169-328X(96)00154-4. PMID 8915591. 
  • Yokoyama M, Nishi Y, Yoshii J, et al. (1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501. 
  • Acharya HR, Dooley CM, Thoreson WB, Ahmad I (1997). "cDNA cloning and expression analysis of NeuroD mRNA in human retina". Biochem. Biophys. Res. Commun. 233 (2): 459–63. doi:10.1006/bbrc.1997.6483. PMID 9144558. 
  • Poulin G, Turgeon B, Drouin J (1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Mol. Cell. Biol. 17 (11): 6673–82. PMC 232521. PMID 9343431. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232521. 
  • Furuta H, Horikawa Y, Iwasaki N, et al. (1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes 47 (8): 1356–8. doi:10.2337/diabetes.47.8.1356. PMID 9703340. 
  • Yoon YS, Noma T, Yamashiro Y, et al. (1998). "Molecular cloning and characterization of the gene encoding human NeuroD". Neurosci. Lett. 251 (1): 17–20. doi:10.1016/S0304-3940(98)00490-X. PMID 9714454. 
  • Miyachi T, Maruyama H, Kitamura T, et al. (1999). "Structure and regulation of the human NeuroD (BETA2/BHF1) gene". Brain Res. Mol. Brain Res. 69 (2): 223–31. doi:10.1016/S0169-328X(99)00112-6. PMID 10366743. 
  • Noma T, Yoon YS, Yamashiro Y, et al. (1999). "Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells". Neurosci. Lett. 272 (1): 45–8. doi:10.1016/S0304-3940(99)00569-8. PMID 10507539. 
  • Malecki MT, Jhala US, Antonellis A, et al. (1999). "Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus". Nat. Genet. 23 (3): 323–8. doi:10.1038/15500. PMID 10545951. 
  • Glick E, Leshkowitz D, Walker MD (2000). "Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter". J. Biol. Chem. 275 (3): 2199–204. doi:10.1074/jbc.275.3.2199. PMID 10636926. 
  • Onions J, Hermann S, Grundström T (2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry 39 (15): 4366–74. doi:10.1021/bi992533u. PMID 10757985. 
  • Mochizuki M, Amemiya S, Kobayashi K, et al. (2002). "The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese". Diabetes Res. Clin. Pract. 55 (1): 11–7. doi:10.1016/S0168-8227(01)00242-X. PMID 11755474. 
  • Ratineau C, Petry MW, Mutoh H, Leiter AB (2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD". J. Biol. Chem. 277 (11): 8847–53. doi:10.1074/jbc.M110747200. PMID 11788592. 
  • Westerman BA, Poutsma A, Maruyama K, et al. (2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mech. Dev. 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979. 
  • Kanatsuka A, Tokuyama Y, Nozaki O, et al. (2002). "Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4". Metab. Clin. Exp. 51 (9): 1161–5. doi:10.1053/meta.2002.34707. PMID 12200761. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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