c-Jun is the name of a gene and protein which, in combination with c-Fos, forms the AP-1 early response transcription factor. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.

section_title =
summary_text = This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [cite web | title = Entrez Gene: JUN jun oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3725| accessdate = ]


Further reading

citations =
*cite journal | author=Bohmann D, Bos TJ, Admon A, "et al." |title=Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. |journal=Science |volume=238 |issue= 4832 |pages= 1386–92 |year= 1988 |pmid= 2825349 |doi=
*cite journal | author=Rahmsdorf HJ |title=Jun: transcription factor and oncoprotein. |journal=J. Mol. Med. |volume=74 |issue= 12 |pages= 725–47 |year= 1997 |pmid= 8974016 |doi=
*cite journal | author=Liu JL, Kung HJ |title=Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style. |journal=Virus Genes |volume=21 |issue= 1-2 |pages= 51–64 |year= 2001 |pmid= 11022789 |doi=
*cite journal | author=Velazquez Torres A, Gariglio Vidal P |title= [Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus] |journal=Rev. Invest. Clin. |volume=54 |issue= 3 |pages= 231–42 |year= 2002 |pmid= 12183893 |doi=
*cite journal | author=Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG |title=The activator protein-1 transcription factor in respiratory epithelium carcinogenesis. |journal=Mol. Cancer Res. |volume=5 |issue= 2 |pages= 109–20 |year= 2007 |pmid= 17314269 |doi= 10.1158/1541-7786.MCR-06-0311

ee also

* C-Jun N-terminal kinases

External links


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