MSX1


MSX1

Msh homeobox 1, also known as MSX1, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomal dominant hypodontia.cite web | title = Entrez Gene: MSX1 msh homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4487| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mostowska A, Kobielak A, Trzeciak WH |title=Molecular basis of non-syndromic tooth agenesis: mutations of MSX1 and PAX9 reflect their role in patterning human dentition. |journal=Eur. J. Oral Sci. |volume=111 |issue= 5 |pages= 365–70 |year= 2003 |pmid= 12974677 |doi=
*cite journal | author=Padanilam BJ, Stadler HS, Mills KA, "et al." |title=Characterization of the human HOX 7 cDNA and identification of polymorphic markers. |journal=Hum. Mol. Genet. |volume=1 |issue= 6 |pages= 407–10 |year= 1993 |pmid= 1284527 |doi=
*cite journal | author=Hewitt JE, Clark LN, Ivens A, Williamson R |title=Structure and sequence of the human homeobox gene HOX7. |journal=Genomics |volume=11 |issue= 3 |pages= 670–8 |year= 1992 |pmid= 1685479 |doi=
*cite journal | author=Ivens A, Flavin N, Williamson R, "et al." |title=The human homeobox gene HOX7 maps to chromosome 4p16.1 and may be implicated in Wolf-Hirschhorn syndrome. |journal=Hum. Genet. |volume=84 |issue= 5 |pages= 473–6 |year= 1990 |pmid= 1969845 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Robert B, Sassoon D, Jacq B, "et al." |title=Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. |journal=EMBO J. |volume=8 |issue= 1 |pages= 91–100 |year= 1989 |pmid= 2565810 |doi=
*cite journal | author=Vastardis H, Karimbux N, Guthua SW, "et al." |title=A human MSX1 homeodomain missense mutation causes selective tooth agenesis. |journal=Nat. Genet. |volume=13 |issue= 4 |pages= 417–21 |year= 1996 |pmid= 8696335 |doi= 10.1038/ng0896-417
*cite journal | author=Zhang H, Catron KM, Abate-Shen C |title=A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 1764–9 |year= 1996 |pmid= 8700832 |doi=
*cite journal | author=Zhang H, Hu G, Wang H, "et al." |title=Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2920–32 |year= 1997 |pmid= 9111364 |doi=
*cite journal | author=Sarapura VD, Strouth HL, Gordon DF, "et al." |title=Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter. |journal=Mol. Endocrinol. |volume=11 |issue= 12 |pages= 1782–94 |year= 1997 |pmid= 9369446 |doi=
*cite journal | author=Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C |title=Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. |journal=Differentiation |volume=63 |issue= 3 |pages= 151–7 |year= 1998 |pmid= 9697309 |doi=
*cite journal | author=Shetty S, Takahashi T, Matsui H, "et al." |title=Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300). |journal=Biochem. J. |volume=339 ( Pt 3) |issue= |pages= 751–8 |year= 1999 |pmid= 10215616 |doi=
*cite journal | author=Bendall AJ, Ding J, Hu G, "et al." |title=Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors. |journal=Development |volume=126 |issue= 22 |pages= 4965–76 |year= 1999 |pmid= 10529415 |doi=
*cite journal | author=van den Boogaard MJ, Dorland M, Beemer FA, van Amstel HK |title=MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. |journal=Nat. Genet. |volume=24 |issue= 4 |pages= 342–3 |year= 2000 |pmid= 10742093 |doi= 10.1038/74155
*cite journal | author=Benzing T, Yaffe MB, Arnould T, "et al." |title=14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28167–72 |year= 2000 |pmid= 10862767 |doi= 10.1074/jbc.M002905200
*cite journal | author=Mehra-Chaudhary R, Matsui H, Raghow R |title=Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. |journal=Biochem. J. |volume=353 |issue= Pt 1 |pages= 13–22 |year= 2001 |pmid= 11115394 |doi=
*cite journal | author=Jumlongras D, Bei M, Stimson JM, "et al." |title=A nonsense mutation in MSX1 causes Witkop syndrome. |journal=Am. J. Hum. Genet. |volume=69 |issue= 1 |pages= 67–74 |year= 2001 |pmid= 11369996 |doi=
*cite journal | author=Blin-Wakkach C, Lezot F, Ghoul-Mazgar S, "et al." |title=Endogenous Msx1 antisense transcript: in vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7336–41 |year= 2001 |pmid= 11390985 |doi= 10.1073/pnas.131497098
*cite journal | author=Lidral AC, Reising BC |title=The role of MSX1 in human tooth agenesis. |journal=J. Dent. Res. |volume=81 |issue= 4 |pages= 274–8 |year= 2002 |pmid= 12097313 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

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