Kruppel-like factor 4 (gut), also known as KLF4, is a human gene. [cite web | title = Entrez Gene: KLF4 Kruppel-like factor 4 (gut)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9314| accessdate = ]

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ee also

* Kruppel-like factors


Further reading

citations =
*cite journal | author=Rowland BD, Peeper DS |title=KLF4, p21 and context-dependent opposing forces in cancer. |journal=Nat. Rev. Cancer |volume=6 |issue= 1 |pages= 11–23 |year= 2006 |pmid= 16372018 |doi= 10.1038/nrc1780
*cite journal | author=Shields JM, Christy RJ, Yang VW |title=Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20009–17 |year= 1996 |pmid= 8702718 |doi=
*cite journal | author=Garrett-Sinha LA, Eberspaecher H, Seldin MF, de Crombrugghe B |title=A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31384–90 |year= 1997 |pmid= 8940147 |doi=
*cite journal | author=Yet SF, McA'Nulty MM, Folta SC, "et al." |title=Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 1026–31 |year= 1998 |pmid= 9422764 |doi=
*cite journal | author=Zhang W, Shields JM, Sogawa K, "et al." |title=The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17917–25 |year= 1998 |pmid= 9651398 |doi=
*cite journal | author=Foster KW, Ren S, Louro ID, "et al." |title=Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF. |journal=Cell Growth Differ. |volume=10 |issue= 6 |pages= 423–34 |year= 1999 |pmid= 10392904 |doi=
*cite journal | author=Segre JA, Bauer C, Fuchs E |title=Klf4 is a transcription factor required for establishing the barrier function of the skin. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 356–60 |year= 1999 |pmid= 10431239 |doi= 10.1038/11926
*cite journal | author=Geiman DE, Ton-That H, Johnson JM, Yang VW |title=Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. |journal=Nucleic Acids Res. |volume=28 |issue= 5 |pages= 1106–13 |year= 2000 |pmid= 10666450 |doi=
*cite journal | author=Zhang W, Geiman DE, Shields JM, "et al." |title=The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18391–8 |year= 2000 |pmid= 10749849 |doi= 10.1074/jbc.C000062200
*cite journal | author=Okano J, Opitz OG, Nakagawa H, "et al." |title=The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. |journal=FEBS Lett. |volume=473 |issue= 1 |pages= 95–100 |year= 2000 |pmid= 10802067 |doi=
*cite journal | author=Higaki Y, Schullery D, Kawata Y, "et al." |title=Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. |journal=Nucleic Acids Res. |volume=30 |issue= 11 |pages= 2270–9 |year= 2002 |pmid= 12034813 |doi=
*cite journal | author=Chen ZY, Shie JL, Tseng CC |title=Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46831–9 |year= 2003 |pmid= 12297499 |doi= 10.1074/jbc.M204816200
*cite journal | author=Yoon HS, Chen X, Yang VW |title=Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2101–5 |year= 2003 |pmid= 12427745 |doi= 10.1074/jbc.M211027200
*cite journal | author=Wang N, Liu ZH, Ding F, "et al." |title=Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. |journal=World J. Gastroenterol. |volume=8 |issue= 6 |pages= 966–70 |year= 2003 |pmid= 12439907 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chen X, Whitney EM, Gao SY, Yang VW |title=Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. |journal=J. Mol. Biol. |volume=326 |issue= 3 |pages= 665–77 |year= 2003 |pmid= 12581631 |doi=
*cite journal | author=Dang DT, Chen X, Feng J, "et al." |title=Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. |journal=Oncogene |volume=22 |issue= 22 |pages= 3424–30 |year= 2003 |pmid= 12776194 |doi= 10.1038/sj.onc.1206413
*cite journal | author=Mao Z, Song S, Zhu Y, "et al." |title=Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor. |journal=Oncogene |volume=22 |issue= 28 |pages= 4434–43 |year= 2003 |pmid= 12853980 |doi= 10.1038/sj.onc.1206508
*cite journal | author=Ohnishi S, Ohnami S, Laub F, "et al." |title=Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 251–6 |year= 2003 |pmid= 12901861 |doi=
*cite journal | author=Hinnebusch BF, Siddique A, Henderson JW, "et al." |title=Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=286 |issue= 1 |pages= G23–30 |year= 2004 |pmid= 12919939 |doi= 10.1152/ajpgi.00203.2003

External links

* [http://www.nextbio.com/b/home/home.nb?q=KLF4&id=34891&type=feature&name=KLF4&synonym= KLF4 microarray expression results and literature]

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