Zinc finger and BTB domain-containing protein 16


Zinc finger and BTB domain-containing protein 16

Zinc finger and BTB domain containing 16, also known as ZBTB16, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.cite web | title = Entrez Gene: ZBTB16 zinc finger and BTB domain containing 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7704| accessdate = ]

ee also

* Zbtb7

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen Z, Brand NJ, Chen A, "et al." |title=Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. |journal=EMBO J. |volume=12 |issue= 3 |pages= 1161–7 |year= 1993 |pmid= 8384553 |doi=
*cite journal | author=Chen SJ, Zelent A, Tong JH, "et al." |title=Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. |journal=J. Clin. Invest. |volume=91 |issue= 5 |pages= 2260–7 |year= 1993 |pmid= 8387545 |doi=
*cite journal | author=Reid A, Gould A, Brand N, "et al." |title=Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors. |journal=Blood |volume=86 |issue= 12 |pages= 4544–52 |year= 1996 |pmid= 8541544 |doi=
*cite journal | author=Dong S, Zhu J, Reid A, "et al." |title=Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3624–9 |year= 1996 |pmid= 8622986 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hong SH, David G, Wong CW, "et al." |title=SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 17 |pages= 9028–33 |year= 1997 |pmid= 9256429 |doi=
*cite journal | author=Koken MH, Reid A, Quignon F, "et al." |title=Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 19 |pages= 10255–60 |year= 1997 |pmid= 9294197 |doi=
*cite journal | author=Lin RJ, Nagy L, Inoue S, "et al." |title=Role of the histone deacetylase complex in acute promyelocytic leukaemia. |journal=Nature |volume=391 |issue= 6669 |pages= 811–4 |year= 1998 |pmid= 9486654 |doi= 10.1038/35895
*cite journal | author=Guidez F, Ivins S, Zhu J, "et al." |title=Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. |journal=Blood |volume=91 |issue= 8 |pages= 2634–42 |year= 1998 |pmid= 9531570 |doi=
*cite journal | author=David G, Alland L, Hong SH, "et al." |title=Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. |journal=Oncogene |volume=16 |issue= 19 |pages= 2549–56 |year= 1998 |pmid= 9627120 |doi= 10.1038/sj.onc.1202043
*cite journal | author=Ahmad KF, Engel CK, Privé GG |title=Crystal structure of the BTB domain from PLZF. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12123–8 |year= 1998 |pmid= 9770450 |doi=
*cite journal | author=van Schothorst EM, Prins DE, Baysal BE, "et al." |title=Genomic structure of the human PLZF gene. |journal=Gene |volume=236 |issue= 1 |pages= 21–4 |year= 1999 |pmid= 10433962 |doi=
*cite journal | author=Ball HJ, Melnick A, Shaknovich R, "et al." |title=The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. |journal=Nucleic Acids Res. |volume=27 |issue= 20 |pages= 4106–13 |year= 1999 |pmid= 10497277 |doi=
*cite journal | author=Zhang T, Xiong H, Kan LX, "et al." |title=Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11422–7 |year= 1999 |pmid= 10500192 |doi=
*cite journal | author=Li X, Peng H, Schultz DC, "et al." |title=Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5275–82 |year= 1999 |pmid= 10537309 |doi=
*cite journal | author=Hoatlin ME, Zhi Y, Ball H, "et al." |title=A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. |journal=Blood |volume=94 |issue= 11 |pages= 3737–47 |year= 1999 |pmid= 10572087 |doi=
*cite journal | author=Melnick AM, Westendorf JJ, Polinger A, "et al." |title=The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2075–86 |year= 2000 |pmid= 10688654 |doi=
*cite journal | author=Hyman J, Chen H, Di Fiore PP, "et al." |title=Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 537–46 |year= 2000 |pmid= 10791968 |doi=
*cite journal | author=Melnick A, Carlile GW, McConnell MJ, "et al." |title=AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. |journal=Blood |volume=96 |issue= 12 |pages= 3939–47 |year= 2001 |pmid= 11090081 |doi=
*cite journal | author=He LZ, Bhaumik M, Tribioli C, "et al." |title=Two critical hits for promyelocytic leukemia. |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1131–41 |year= 2002 |pmid= 11106752 |doi=

External links

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