POU3F2


POU3F2

POU domain, class 3, transcription factor 2, also known as POU3F2, is a human gene.cite web | title = Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5454| accessdate = ]

PBB_Summary
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summary_text = N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression. [supplied by OMIM] cite web | title = Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5454| accessdate = ]

ee also

* Octamer transcription factor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hara Y, Rovescalli AC, Kim Y, Nirenberg M |title=Structure and evolution of four POU domain genes expressed in mouse brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3280–4 |year= 1992 |pmid= 1565620 |doi=
*cite journal | author=Schreiber E, Harshman K, Kemler I, "et al." |title=Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins. |journal=Nucleic Acids Res. |volume=18 |issue= 18 |pages= 5495–503 |year= 1990 |pmid= 2216722 |doi=
*cite journal | author=He X, Treacy MN, Simmons DM, "et al." |title=Expression of a large family of POU-domain regulatory genes in mammalian brain development. |journal=Nature |volume=340 |issue= 6228 |pages= 35–41 |year= 1989 |pmid= 2739723 |doi= 10.1038/340035a0
*cite journal | author=Eisen T, Easty DJ, Bennett DC, Goding CR |title=The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression. |journal=Oncogene |volume=11 |issue= 10 |pages= 2157–64 |year= 1995 |pmid= 7478537 |doi=
*cite journal | author=Atanasoski S, Toldo SS, Malipiero U, "et al." |title=Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16. |journal=Genomics |volume=26 |issue= 2 |pages= 272–80 |year= 1995 |pmid= 7601453 |doi=
*cite journal | author=Thomson JA, Murphy K, Baker E, "et al." |title=The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. |journal=Oncogene |volume=11 |issue= 4 |pages= 691–700 |year= 1995 |pmid= 7651733 |doi=
*cite journal | author=Schreiber E, Tobler A, Malipiero U, "et al." |title=cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif. |journal=Nucleic Acids Res. |volume=21 |issue= 2 |pages= 253–8 |year= 1993 |pmid= 8441633 |doi=
*cite journal | author=Atanasoski S, Schreiber E, Fontana A, Herr W |title=N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3. |journal=Oncogene |volume=14 |issue= 11 |pages= 1287–94 |year= 1997 |pmid= 9178889 |doi= 10.1038/sj.onc.1200953
*cite journal | author=Petersenn S, Rasch AC, Heyens M, Schulte HM |title=Structure and regulation of the human growth hormone-releasing hormone receptor gene. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 233–47 |year= 1998 |pmid= 9482665 |doi=
*cite journal | author=Kuhlbrodt K, Herbarth B, Sock E, "et al." |title=Cooperative function of POU proteins and SOX proteins in glial cells. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16050–7 |year= 1998 |pmid= 9632656 |doi=
*cite journal | author=Waragai M, Lammers CH, Takeuchi S, "et al." |title=PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival. |journal=Hum. Mol. Genet. |volume=8 |issue= 6 |pages= 977–87 |year= 1999 |pmid= 10332029 |doi=
*cite journal | author=Smit DJ, Smith AG, Parsons PG, "et al." |title=Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. |journal=Eur. J. Biochem. |volume=267 |issue= 21 |pages= 6413–22 |year= 2000 |pmid= 11029584 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jaegle M, Ghazvini M, Mandemakers W, "et al." |title=The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. |journal=Genes Dev. |volume=17 |issue= 11 |pages= 1380–91 |year= 2003 |pmid= 12782656 |doi= 10.1101/gad.258203
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Goodall J, Martinozzi S, Dexter TJ, "et al." |title=Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2915–22 |year= 2004 |pmid= 15024079 |doi=
*cite journal | author=Goodall J, Wellbrock C, Dexter TJ, "et al." |title=The Brn-2 transcription factor links activated BRAF to melanoma proliferation. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2923–31 |year= 2004 |pmid= 15024080 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Cobrinik D, Francis RO, Abramson DH, Lee TC |title=Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells. |journal=Mol. Cancer |volume=5 |issue= |pages= 72 |year= 2007 |pmid= 17163992 |doi= 10.1186/1476-4598-5-72

External links

*

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Look at other dictionaries:

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  • POU-Familie — Die POU Familie ist eine Gruppe von Transkriptionsfaktoren mit einer hochkonservierten Homöodomäne. Im menschlichen Genom wurden 15 POU Gene gefunden. Das Genom der Modellorganismen Drosophila und Caenorhabditis elegans weist dagegen nur fünf… …   Deutsch Wikipedia

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  • Octamer transcription factor — An octamer transcription factor is a transcription factor which binds to the ATTTGCAT sequence.[1] Examples include: Oct 1 POU2F1 Oct 2 POU2F2 Oct 3/4 – POU5F1 Oct 6 – …   Wikipedia


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